ID   A0A0N0PCX3_PAPMA        Unreviewed;       331 AA.
AC   A0A0N0PCX3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=NAD-dependent epimerase/dehydratase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=RR48_03682 {ECO:0000313|EMBL:KPJ14132.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ14132.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ14132.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ14132.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ14132.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA   Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA   Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR   EMBL; KQ460542; KPJ14132.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N0PCX3; -.
DR   STRING; 76193.A0A0N0PCX3; -.
DR   InParanoid; A0A0N0PCX3; -.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF11; LD23561P; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240}.
FT   DOMAIN          13..44
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   DOMAIN          103..208
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   331 AA;  36707 MW;  DE434443929B528E CRC64;
     MSESTGEIKP RAVVLGGCGF IGRNLVEYLI SNDLVSELRV VDKTPPQLAF LNPTHTKIFE
     DPRVEYKSAN LINPSPKTSA TPEAYRCIVG PLRNLFVLVL LQPQKEDCSI EPWTVEGRMK
     SKVEQELRSL EPELSYTVLR PAIVYGIGDR RSLTPRLLIG AIYKHLGQTM KLLWTADLKM
     NTVHVEDVCR AAWTLARTPE AQGQVYNVVD EADSTQGSLA KLVSEIFKIK HDYYGTAIST
     LAKSDISAVV EQANDTHLSA WADICRRHDI PHTPLDPAAG AELLLNRQLC LSGARIAAIL
     RPRHLAPTAA ALTQVLEDYA SMNLFPKEFL L
//