ID A0A0N0TP38_9ACTN Unreviewed; 381 AA.
AC A0A0N0TP38;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:KOX18316.1};
GN ORFNames=ADL05_07675 {ECO:0000313|EMBL:KOX18316.1};
OS Nocardiopsis sp. NRRL B-16309.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1519494 {ECO:0000313|EMBL:KOX18316.1, ECO:0000313|Proteomes:UP000037694};
RN [1] {ECO:0000313|Proteomes:UP000037694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16309 {ECO:0000313|Proteomes:UP000037694};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOX18316.1}.
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DR EMBL; LGEC01000058; KOX18316.1; -; Genomic_DNA.
DR RefSeq; WP_053616158.1; NZ_LGEC01000058.1.
DR AlphaFoldDB; A0A0N0TP38; -.
DR STRING; 1519494.ADL05_07675; -.
DR PATRIC; fig|1519494.3.peg.1678; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000037694; Unassembled WGS sequence.
DR GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000037694}.
FT MOD_RES 200
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 381 AA; 40222 MW; 831EA794B1A8D675 CRC64;
MTFDGFETLA IHAGQEPDTG TGAVVVPIYQ TSTYAQDGVG GLRQGYEYSR TGNPTRAALE
ECLAALEEGS RGLAFASGMA AEDTLLRTIL SPGDHVIIPG DAYGGTFRLI STVVERWGVT
WDAVDQSDPE AVRAAVRPET RAVWTETPTN PLLNITDIEA VAAIAHDAGA LHVVDNTFAS
PYLQRPLALG ADVVVHSTTK YLGGHSDVVG GALVVADAEL GERLAFHQNT MGAVPGPFDS
WLTLRGVKTL GVRMDRHSAN AERVVAALVD HPAVRRVYYP GLDAHPGHKV AERQMRAFGG
MVSFALRDGE KAALALCERT EVFTLGESLG GVESLIEHPG RMTHASTAGS PLEVPADLVR
ISVGIESGDD LVADLLGALE G
//
