ID A0A0N0U796_9HYME Unreviewed; 526 AA.
AC A0A0N0U796;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=TNF family profile domain-containing protein {ECO:0000259|PROSITE:PS50049};
GN ORFNames=WN51_10122 {ECO:0000313|EMBL:KOX79074.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX79074.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX79074.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX79074.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX79074.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; KQ435716; KOX79074.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N0U796; -.
DR STRING; 166423.A0A0N0U796; -.
DR OrthoDB; 5403423at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 62..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 375..445
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 135..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..150
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 60439 MW; 17B6C36D95D1D216 CRC64;
MTSVLSDENS KVARMKQKLM NDVHVKEETR SFLSFFRENL SISQSDLEQG FNKHRFRPNR
NTILSVTALL IALLCLGLES WRFHCSLVNA REIEELKRSV ESLKHRFLEE DLLDELKAFE
EQVVILFFSH DDDDDDPDEA DIDNANYDSN YDDDDAFSSR DYSRPMFGAR PSDFPDSSST
IAPVPSPPEI SADKTILKWA AATVAAYKAE AKHSQELQRR NYRTASHLQE QSDNRENNTK
QKRNVLDDTD DVDDLLLNWR ANLKRKRSTD KENHSSKRWF VKRQESYKGT LTSGTSFRET
LKNSSAEEQQ NTSIVVSSRH PPKKYNTYTS SNNTETSSLE RDDKLSVEAR TATYNRTRKV
AHKLRKNMNS REVVAIHYHG DGSEISSRDQ NAGNGKIRHG SSTFKAWKPS DWVTDSGMSK
HFSMSEGRLT IYETGLYLIY AQIHYNDDHD EIGFHLVVND RPVLQCMIDN SGHSRNISQT
CFSAQLAHLR KHDVLIFKEA SSPRFVIFDQ KNSFFGLVKL GELKKL
//
