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Database: UniProt
Entry: A0A0N1FW91_9ACTN
LinkDB: A0A0N1FW91_9ACTN
Original site: A0A0N1FW91_9ACTN 
ID   A0A0N1FW91_9ACTN        Unreviewed;       673 AA.
AC   A0A0N1FW91;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   05-JUL-2017, entry version 14.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=OK074_3868 {ECO:0000313|EMBL:KPI07793.1};
OS   Actinobacteria bacterium OK074.
OC   Bacteria; Actinobacteria.
OX   NCBI_TaxID=1592327 {ECO:0000313|EMBL:KPI07793.1, ECO:0000313|Proteomes:UP000037991};
RN   [1] {ECO:0000313|EMBL:KPI07793.1, ECO:0000313|Proteomes:UP000037991}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OK074 {ECO:0000313|EMBL:KPI07793.1,
RC   ECO:0000313|Proteomes:UP000037991};
RA   Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT   "Draft genome sequences for four actinobacteria strains OK006 OK074
RT   OV450 and OV320.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPI07793.1}.
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DR   EMBL; LJCV01000251; KPI07793.1; -; Genomic_DNA.
DR   EnsemblBacteria; KPI07793; KPI07793; OK074_3868.
DR   PATRIC; fig|1592327.3.peg.6080; -.
DR   Proteomes; UP000037991; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000037991};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037991}.
FT   DOMAIN      366    494       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      580    649       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     374    381       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   673 AA;  74939 MW;  89715B3B90938CF9 CRC64;
     METKDEHWIR RCQPLALVAD TALLAVPNEF AKGVLEGRLA PIVSETLSRE CGRPIRIAIT
     VDSSAESPPP STPPRYEDSE LPTAPGQSTG RDAYDSPNRP AYESASRDPY ESAAREPYDN
     KARDGYDGQS RDPYDSPNRD GGHDAPPRDG YDGRARDPYE SQTSQIRDNR DPYEGYGRHR
     ADDHRSGGRP EHLAGGGPGD QLPHPRADQL PTARPAYPGE YQRPEPGAWP RTDRDDYGWQ
     QQRLGYPDRD PYATPSSAQD YARPPYEQQR PDYDGGPRGD FEQQRQDYDQ RPDRRELSEP
     PHRGGGMSNS GAPGPLAAKP APASGPGGEP TARLNPKYLF DTFVIGASNR FAHAAAVAVA
     EAPAKAYNPL FIYGESGLGK THLLHAIGHY ARSLYPGTRV RYVSSEEFTN EFINSIRDGK
     GDSFRKRYRE MDILLVDDIQ FLADKESTQE EFFHTFNTLH NANKQIVLSS DRPPKQLVTL
     EDRLRNRFEW GLITDVQPPE LETRIAILRK KAVQEQLNAP PEVLEFIASR ISRNIRELEG
     ALIRVTAFAS LNRQPVDLGL TEIVLKDLIP GGEDSAPDIT AGAIMAATAD YFGLTVEDLC
     GTSRGRALVT ARQIAMYLCR ELTDLSLPKI GAQFGGRDHT TVMHADRKIR NLMAERRSIY
     NQVTELTNRI KNG
//
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