ID A0A0N1I3Q5_LEPSE Unreviewed; 610 AA.
AC A0A0N1I3Q5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Putative signal recognition particle receptor like protein {ECO:0000313|EMBL:KPI85688.1};
GN ORFNames=ABL78_5268 {ECO:0000313|EMBL:KPI85688.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI85688.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI85688.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI85688.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}.
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family.
CC {ECO:0000256|ARBA:ARBA00008531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI85688.1}.
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DR EMBL; LJSK01000172; KPI85688.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1I3Q5; -.
DR EnsemblProtists; KPI85688; KPI85688; ABL78_5268.
DR VEuPathDB; TriTrypDB:Lsey_0172_0200; -.
DR OMA; AYWLQQN; -.
DR OrthoDB; 5475029at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0005785; C:signal recognition particle receptor complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005047; F:signal recognition particle binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR CDD; cd14826; SR_alpha_SRX; 1.
DR CDD; cd17876; SRalpha_C; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.140; Signal recognition particle SRP54, nucleotide-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007222; Sig_recog_particle_rcpt_asu_N.
DR InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR InterPro; IPR036225; SRP/SRP_N.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR InterPro; IPR042101; SRP54_N_sf.
DR PANTHER; PTHR43134; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43134:SF1; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF04086; SRP-alpha_N; 1.
DR Pfam; PF00448; SRP54; 1.
DR Pfam; PF02881; SRP54_N; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SUPFAM; SSF47364; Domain of the SRP/SRP receptor G-proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00300; SRP54; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KPI85688.1}.
FT DOMAIN 583..596
FT /note="SRP54-type proteins GTP-binding"
FT /evidence="ECO:0000259|PROSITE:PS00300"
FT REGION 142..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 610 AA; 65608 MW; 71F56393FE5E0432 CRC64;
MIDTISIISD SGVVLWQQSS HETGRRSMVN KFIQDVLLED RAGLTQYSVG DYQLRWALEN
DANFFVVAVY PKFFKPHYMQ NFLRDIASAF AKKHGKQTAM NLFSSVGTDS STASAGSSNL
MDFSTEYTAL LVKFNASEEV ASRQGAHDDG GANIGAEASE DAAEEEEVVR GEEGRGGGGT
AEAAEDGGHH ALQKSGRIIA AKSGRRLVIG GAPGAATGVE TATAAAPPSA TGASKKRSKK
PTKWDSPSAV HDPMVEKQSH QKKATEAELQ AQADIQRETY IKRLPNGTIA PVKEREWEGQ
SRGRLATWLR SYMGTRSVDK EDLGNIIPSL REKLIAKNVA VEVAEHVCKS VEASLAGKRL
GTFDSLYKTV DNAMTASLHR ILQPKREVNI LRDVAAARAA GKPYSIVVCG VNGVGKSTSL
AKMTYWLQQN GNTVLLAAGD TFRHGAVEQL EVHGRCLGVP VFQLGYGSDP SAVAAAAITQ
AGKQHTNVVM IDTAGRMQDH ESRMRALAKL IHDNQPDLVL FVGEALVGNN GIDQLRKFNQ
CLVDFAPVGA PSRCIDGIVL TKFDTIDDKV GAALSMVYEL GQPIVFVGVG QTYQDLKVIE
PEVVVSALMK
//
