ID A0A0N1I9R2_PAPMA Unreviewed; 310 AA.
AC A0A0N1I9R2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Suppressor of cytokine signaling 6 {ECO:0000313|EMBL:KPJ14291.1};
GN ORFNames=RR48_05269 {ECO:0000313|EMBL:KPJ14291.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ14291.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ14291.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ14291.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ14291.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ460499; KPJ14291.1; -; Genomic_DNA.
DR RefSeq; XP_014359524.1; XM_014504038.1.
DR AlphaFoldDB; A0A0N1I9R2; -.
DR STRING; 76193.A0A0N1I9R2; -.
DR GeneID; 106711664; -.
DR KEGG; pmac:106711664; -.
DR InParanoid; A0A0N1I9R2; -.
DR OrthoDB; 5401079at2759; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd09923; SH2_SOCS_family; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF28; SUPPRESSOR OF CYTOKINE SIGNALING 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 168..261
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 256..300
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 310 AA; 35730 MW; DC64CC955E1B6030 CRC64;
MNKNYERCTN CNRRKWLASG CLRKWLKPME CKHLQRSIDS KRDFNNTDIV NCVVLPDRKT
SLNANKFVKF WKNKFFMTGS VRSLQRYFSN KNNGGEYICS FNKTCDPSTS SDKQTVSNPC
YDIKKDTSSD KITIKCQHSE GHSVLRGHHQ HASMETCAIY CQLSKHGWYW GGITSSEAEE
LLAGQHDNVF LVRDSYDSRH ILCVSFRCVG RTLHARLRHA NGLFSLNNET FVPANRISEH
CATVDVKSNL FEMPVKLARP LNRFARLDSL QMICRFVIRQ TVDTNVWQKL PLPPNLITYV
SLGSDYIVQT
//
