ID A0A0N1IGH5_PAPMA Unreviewed; 1753 AA.
AC A0A0N1IGH5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN ORFNames=RR48_04473 {ECO:0000313|EMBL:KPJ14613.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ14613.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ14613.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ14613.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ14613.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; KQ460466; KPJ14613.1; -; Genomic_DNA.
DR STRING; 76193.A0A0N1IGH5; -.
DR InParanoid; A0A0N1IGH5; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 5.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF00520; Ion_trans; 6.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 5.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 772..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 908..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 955..982
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1071..1093
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1113..1139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1191..1211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1223..1243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1334..1354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1428..1449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1570..1604
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 583..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..662
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 184
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 522
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1085
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1753 AA; 200185 MW; 5F4A9F724D114C85 CRC64;
MILTTIFANC IALAVYTPYP SGDSNYTNSV LEKIEYIFLV IFTGECVMKI IAYGFVMHPG
SYLRNGWNLL DFTIVVIGMV STVLSSIFKD AFDVKALRAF RVLRPLRLVS GVPSLQIVLN
SILKAMVPLL HIALLVIFVI IIYAIIGLEL FSGKMHKSCY NKLTDYFDNF GLSMLTVFQC
ITLEGWTDVM YNIQDAMGNS WEWIYFISMV ILGAFFVMNL ILGVLSGEFS KEREKAKNRG
DFQKLREKQQ LEEDLKGYLD WITQAEYLEP LADQHDTADQ KRDYGMGQTT SENDSTDNLG
IEVLTEQKKK MSIGECWKKD FDKVNRRMKR ACRRAVKSQT FYWLIIVLVF LNTVVLASEH
YHQPSWLDLF QEYGNAFFVA LFTLEMLVKM YSLGLQGYFV SLFNRFDCFV VVGSISEMVL
TKTEVMPPLG ISVLRCVRLL RVFKVTKYWR SLSNLVASLL NSIQSIASLL LLLFLFIMIF
ALLGMQVFGG KFNYDPVEEK DRHNFDCFWQ ALLTVFQILT GEDWNAVMYE GIKAYGGVGS
VGILACIYFI ILFICDILLN VFLAIAVDNL ADAESLTNIE KEEGQAAEEK EGGSIIAEGG
HADTDDEYIH DEDAYTTDNS EREYEETGSE GEQQEEIEGE EDIGPEEEIG EERLEDEQER
DDLDMMESHQ RNHIEFDDEP RLKRKPTTSS ARPRRLSEVD IRDSKKPIPD ASSFFIFSKT
NRFRVLCYKL SASSTFGNII LVCILFSSAM LAAEDPLDAA QRGFRNWLLS QFDMFFTGIF
TLELFLKLVT YGLVLHPGAF LRSAFNVLDM LVVCVSLISM SFKFRVLCYK LSASSTFGNI
ILVCILFSSA MLAAEDPLDA AQRGFRNWLL SQFDMFFTGI FTLELFLKLV TYGLVLHPGA
FLRSAFNVLD MLVVCVSLIS MSFKSGSISV VKILRVFRVL RPLRAINRAK GLKHVVQCVI
VAIKTIGNIL LVTSLLQFMF AVMGVQMFKY VVKCVIVAIK TIGNIMLVTY LLQFMFAVVG
VQLFKGKFFR CNDISKMTKE ECQGTYLVFE NRNYVVRDRE WRRNDFHFDN VMKGMLTLFT
VSTFEGWPGL LYVSIDSNAE DRGPITNFRP IVAAYYIIYI IIIAFFMVNI FVGFVIVTFQ
NEGEQEYKNC ELDKNQRNCI EFALKAKPIR RYIPKHRIQY KVWWFVTSQP FEYAIFVLIM
INTITLAMKY HNQSPEYSKT LDLLNMLFTA VFALEFIFKL AAFRFKNYFG DAWNTFDFII
VLGSIIDIVV SQVNELKNQG SGLPRAHVVK ESSIPSINFF RLFRVMRLVK LLSRGEGIRT
LLWTFIKSFQ ALPYVALLIL MLFFIYAVVG MQVFGKIAID DDTPITRNNH FQTFPQAILV
LFRSATGEAW QDIMMGVSPE PEVKCDKNYE DEGEEGGGTC GSVLAFPYFI SFYVLCSFLI
INLFVAVIMD NFDYLTRDWS ILGPHHLDEF IRYNNVFSTD ILFSETHSFG KLCPHRVACK
RLVSMNMPLN SDGTVLFNAT LFAVVRTSLK IKTDGNIDDC NTELRAVIKK IWKRTSPKLL
DQVVPPPGDP NEITVGKFYA TFLIQDYFRR FKKRKEQEMR QSDEQNHQMT LQAGLRTLHE
AGPELKRAIS GNLDDITADT DVPMHRRNHS LFGGVWSSIR RHGPNKHFNR HRKPGEGPTE
AVGNHLSSMM QKEYGVGPLP LAPNLANGQP KEQIPLRPLI LNGESEKIYQ VLERTTNDLK
NAIYKGSETC DSI
//
