ID A0A0N1IJ41_LEPSE Unreviewed; 1641 AA.
AC A0A0N1IJ41;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Putative calpain {ECO:0000313|EMBL:KPI85324.1};
GN ORFNames=ABL78_5606 {ECO:0000313|EMBL:KPI85324.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI85324.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI85324.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI85324.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI85324.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LJSK01000194; KPI85324.1; -; Genomic_DNA.
DR EnsemblProtists; KPI85324; KPI85324; ABL78_5606.
DR VEuPathDB; TriTrypDB:Lsey_0194_0020; -.
DR OMA; TEVCAHT; -.
DR OrthoDB; 147919at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProt.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.60.120.380; -; 5.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF421; PUTATIVE-RELATED; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 6.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
FT DOMAIN 725..1038
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 539..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1641 AA; 182670 MW; AB0916C8E883832B CRC64;
MPSNVELYDY YCRRSACHPN SSVKTFLEST GRTELETLDV SGNYLGQRGL IPVLDLVKNT
KTIQTLDVSN NELGVEQVQH LAYCLALHPN MRSVRLCNTG LHDGHVEVLL QLLSMNKSIE
ELILEGNHLT PPRIREVEEA LAHNRRTQQL RRAEACTHSA YLTEKAATAT VAKRTFSAVL
SGNIPAAESG GYVHYATWFK NPQFCVQTSR TSRVSFVLEC TQDNSGTNQM GLMVLRHDGV
HRAVEIDEMT VVAESPVSEQ HCVVEALLNH EESYVVMPYT FNPGHALPFR LTATLINDHT
AQKEGWITLE RLNARYDWCT CSIEDGAWTA ANAGGSGSNT TWRNNDMYHL TNCSKAEAPD
SCSSNGTPAT MIGALPSDTP TVSIYILLVK EVDPYCNDER AIGIDVMTHG EHHPNAPPLF
YSSDVVYASL PHERKTFALL KLQLPASNLD LYVVPSTELP GQTGTYTLTV FSSIEVQLAR
SVFPHGWRYR VMDGAWDEMY CGGCRAECSS WKSNPSFEVH VERVAQPLIA CVEVRPLPPP
AADPEVPPQS ADASVATGEE QEDEREEDES PEAALRRAEL EAFYQRHRSQ KLEVGVMAVD
TVAPAFSMMA TSAQKEHAAA VVVSPTRPDL YVVPMLRHAA EIAAYTLELF SPSPFVVEST
DAVCLATRER QAQLAAYELE SKKRAAILRA AEEQHQQSDE GLQDSASLQA ERKTILEKAS
QTGLPYVDRD FPRGTSSLFL DPAGPPPLDF PMQTTWKRVS EVSQPVREIC PANMSPPYPY
GPRHWFASVL QAVAVKPSWL ARIFVRYDPE AGFAQFSFYK QDDWVGVTVD DFLLVDNQNE
LVYGRSSRSS GDAHNFFFPL AEKAYAKLHR CYEALEPKVN PDQTTLALLC QGLMDVTSGL
TSVVRIRSCD KSDELPVEEK DRLWRKLKSA IDASLLCSLM LDSGGAVTRE RSHVGLLPDR
LYGVMDARFV EQQRLVKIRL FDSSDSDEWS GKWAFSSPRW TPTLRDVLHY HAAETHTAWL
HFDEVLYYFT HVLMTEVCLR KVNVAGSFAE ALDHEPAAAA LSLRNPQYAL NVSLSDTAGD
TAMEVNISVH RRDPRLDITR TRGATARLKT RLGFAVFATE DNTRRLSHVA DNQLLQLVKP
SIERDQHVTL QLTPDFLRTQ KITVMPFREN LRDPDVSYTV SASCAAGTPA GATVQLKHVV
PNMSTIVSGQ WAAEVKTGPP TFPQWRNNPQ FFLSAAQEME VTVTLRPTCM TTATLGFTLH
RTRHCSSFLN FEPATVVASA VSSVAGAAPS CVVRLAGMAE RRGMPYVLVP YSSDGTGEFQ
LEVVGNQPVH LRPIEPRLDW HRMRYNVSIS AANGNMGGNP ENTPSWRFNS QLALTFPVER
DGRLFISAKR LRSADPRVKI GMLLLHAGPA VTGNYRRCII YNDDDVVAKS TDSQAESVLD
TEVSLPAERG ALILVVYADQ PYKEAEVELS FYTAPTLEMQ PVEEWPRVLM QEGSWNLGTT
AAGSRTNFAS WINNPFFCLS VLRPTKVTLL LVQYPRDHEH PVVKRYGTQK ALLPPPLMHP
DRCTAIQLSV AKFDEKLTEV VSTAPTTRAE AYIVVELSPE QPYLVVPCTK EPQHDGDFKL
FAFADHPIEL YLTEKPRLPY V
//
