ID A0A0N1P001_9EURO Unreviewed; 450 AA.
AC A0A0N1P001;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=AB675_1195 {ECO:0000313|EMBL:KPI38225.1};
OS Phialophora attinorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX NCBI_TaxID=1664694 {ECO:0000313|EMBL:KPI38225.1, ECO:0000313|Proteomes:UP000038010};
RN [1] {ECO:0000313|EMBL:KPI38225.1, ECO:0000313|Proteomes:UP000038010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 131958 {ECO:0000313|EMBL:KPI38225.1,
RC ECO:0000313|Proteomes:UP000038010};
RA Moreno L.F., Stielow B.J., de Hoog S., Vicente V.A., Weiss V.A.,
RA de Vries M., Cruz L.M., Souza E.M.;
RT "Draft genome of the ant-associated black yeast Phialophora attae CBS
RT 131958.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI38225.1}.
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DR EMBL; LFJN01000020; KPI38225.1; -; Genomic_DNA.
DR RefSeq; XP_017998188.1; XM_018140851.1.
DR AlphaFoldDB; A0A0N1P001; -.
DR STRING; 1664694.A0A0N1P001; -.
DR GeneID; 28732721; -.
DR OrthoDB; 1649721at2759; -.
DR Proteomes; UP000038010; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000038010};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..344
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 450 AA; 50956 MW; BABF7C559FE74E2F CRC64;
MDDNVRYTIY GVLIVLAHVI WWLWRLNRTL KATPDSLKKF VTPWEPEKIR EAYKNVRSAE
EASRPHLRSK KGRRYVIVGG SGTVGSWIVQ HLLWRGEDPQ AIRILDIVAP TRPEATDLNF
IKTDVADDES VEAAYNAAWP ERVRNQPLTV FHCAAKIYVA DASLRYLDKY VPVNVDGVRF
SMEAAKKTGC DCFIATSSSS VSLLSTNWWS IAGPTNYIQL RPNSEPLLEL DSDEFSNCYQ
YTKVLMEDLV SKANEEGFRT GIIRPGHAIY GHGTNNDNSV TWRNLRMKGG ITWLKPCVMN
FVHCINVSLG QLALEDRLLV DPKVSGKGYA ITERPELYHN YYRVLETLGG CTFPDVQPLM
MLSLAQMIEM YEWVRSYLPL PAITGDLHNL QPGMLKMCML HVLFDSKAAA KDLGYQPAFD
TLEGLCMTVK DWNEKESSKN GSIDSKSNLF
//