ID A0A0N1PEQ6_PAPXU Unreviewed; 4298 AA.
AC A0A0N1PEQ6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Spectrin beta chain, brain 4 {ECO:0000313|EMBL:KPJ04733.1};
GN ORFNames=RR46_01222 {ECO:0000313|EMBL:KPJ04733.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ04733.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPJ04733.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ04733.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ04733.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR EMBL; KQ458863; KPJ04733.1; -; Genomic_DNA.
DR STRING; 66420.A0A0N1PEQ6; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd21193; CH_beta_spectrin_rpt1; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 16.
DR Gene3D; 1.20.58.60; -; 24.
DR Gene3D; 1.10.418.10; Calponin-like domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 29.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 31.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 2.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 38..141
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 227..332
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 913..970
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 3861..3969
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 3750..3850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4005..4149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4180..4205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4225..4298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 655..696
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1499..1543
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1589..1649
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2801..2835
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3193..3251
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3394..3453
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3599..3626
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3816..3830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4036..4054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4126..4146
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4252..4266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4268..4283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4298 AA; 486254 MW; DD2B9C6441728E7D CRC64;
MSVCTPIRIT SRRGDLWPVD ALKFEQGRIK ALQEERLHIQ KKTFTKWVNS FLQKARMEVE
DLFVDLGDGR RLLKLLEIIS GERLPRPNSG RMRVHKIENV NKSLGFLHTK VRLESIGAED
IVDGNPRLIL GLIWTIILRF QIQEIEIDVD EENESSEKKS AKDALLLWCQ RKTSGYHGVR
LESIGAEDIV DGNPRLILGL IWTIILRFQI QEIEIDVDEE NESSEKKSAK DALLLWCQRK
TSGYHGVHIH NFTDSWRSGL GFNALIHAHR PDLFRWAEVP QADHVETLNH AFDVAHNHLG
IPRLLDAEDV DTSRPDEKSV MTYVASYYHT FARMKNEQKS GRRIANIIGQ MMDCDSRKGE
YGRLMSALLE WIRLKILELN GRELPNSLDG IQRLLLAFKQ YRTVEKPPKY KERSEVEALY
FHINTMQKSL VGEAWAPNEG HLPQDLERAW QKLEQAEHAR ELALRTELLR QQRLEQLNYK
FNTKSVLRKG YLKEMIQVLS DPRYGSNLAQ VDATVKKHEA ISADILARTE RFEDLSAMAG
ELVREQYHGA EAVSRTEQAV LARWRELLEL LERHRTSLAR LAHLMALLRE ADAVAHTLLE
MKAQFQSEEV GRHLVDVERL LQAHALQELQ LGALDESIRR LVRQGAAAEG PPQPTQQLAA
QLAKLEDACD SLMAAAKDRK ARLEDARNLY QFLEDHDEEE GWVTEKQRIC RAEVAAKDLR
GVLALRQKHT ALLHELRARD LVAQRHRERG QSLIEAKHPK SAEVERRLAA LSKQWELLRQ
LAEARDKQLA DAAEAHQFYG DANESESWMK EKRALVGTAD CGRDAAGAGA LLARHRLLHG
ELQAYEPELQ QLRAAADRLQ SAGIHELQLP TEVEAGPALE EEEWVNETRL VPTEVWEEEP
VERLEHRTVT EERSVPQVKA LYAFTGQGIS MAKGEVMFLM NKTNPDWWSV RKADRTDGFV
PANYVREIEP RVVPVQVRRP EKVRTVQRVK KTVLVKQVVP VRRGTTRPAR RASRAQPVAL
AKAPAVGERM QHIEQQYGEL VKLSEARRLQ LEDAIKLYSF FAECDDFDKW IKEKEKMLRT
DDPEDSVDTA KRKYEKFVTD LSAASKRLEH IEAAAEELVA AQHGQAARAT ARRQQLRQQW
ARLLRLKEQK EMHLEGASSV ELFQRTCDEA LEWMCEKEQQ LAGVGGAGGG AGADLRTVRA
LQRRHAQLER ELEPLREKVN TVALLADSVK SQYPSERGNV EARQQQLQQA WLRCQAQAAE
RRSRLESAVG LQVFASNSAQ LHDTVQKVRE QLQQEVTAKD VATAEALYKQ HQELHDDIKG
YDDEFKEVIG LGKQLLANNP SLTDVAEKIK TLEAEQKALH KEWQEKEVVL KQGVQLQTFN
READQIDASS GAHEAFLEYN QCGSSVDEVE ALLKQQEELE ARLGAQDERL AAFVQRAAAL
ERQQPRHYAE KHIAARRAAV VQRRDNVRQA AAERRRALLA SLAHQQFVAA ADELQTWILD
KTRTAKDQSY RDLANLERKL QKHEAFEREL QANEKQLRNV ESIGQSLQKS DPARAEEVSE
RLRDLQTAWE ELVAASRDKG SKLRQAAQQR QHRRAVEDAK ARLVDLERAL KSEEIGTDLR
SCKRLLNQHQ ALEQELSQWE SRAKALAAQG EDLVSGGHFD GAAIERDSAA LLAALDKLRP
RAAARRAALE TSMRLHKFAA EVSGELDWLQ ERQAAASSTA LPSDLHAAQA AQKKHAKLRA
ELLGRRPLIE RVLAQGRTLV EEEHPQKEKI EELSDELEAA YSRVSAAAEE RGARLEAALR
AQQFLHEALE VDSWLADKAA ALASADVGAD RHRATQLLTR HKAVELELDT YAAIIAEMGH
VAASMGQPEL VERHALLAGS LARLQRLAQQ RQGALVESVC RHEYLAESAE LESWIQEQYA
AASSEDYGQD YEHLLILRSK FEELRHRVES GAERFNQCEE LAKKLLASDS PYIADIERRQ
EALGESWQRL VEQIGSRAQR LHAAGEIHRF HRDAGELVGR ASERAARLAA PPPPRDLRAA
TALLRDHDTL ETDLLAIDAQ MQVLQEEVQQ IALRQRALSD AWAALRSAAD QRRLLLHQHL
ELHQFLSEVR DVLTWSAALR GGMAGAARAR SAAAAQAQRA HHDALRAEID ARDDDFRLAL
ERAQRLIDAR HPAAQEIAEK CEAVVEERAQ LHSAWAARQV ALDQLHDLHC FLRDAKQLHE
LCASQEAALS TEISPTCSVE EVDNQLKKHE AFEKLLATQD EKLTTLNNHG DKLLQQNHVE
SQRIADELQQ INERRKKLYD SAALRREQLV RSRARAQFAR DAAEARAWVA DKLAQLPAQA
GEVTDLEDKI KKLKKHQAFT AELAAHKARL QEVQALAEQL RPDAEVDRQL QQLQNDWQLL
ETATEQRGRG LEEAQDMLEF NQHLDKIEAW IRDKEMMVQA HELGRDYEHC SALLRKLDDL
DSDMKVDDKR VRALVALADK LLQKGGGAGA QAGGVAARRD AVLGRWRALS GALQAYRDRL
DAALLLHSFN RDVEETAERI SKKAAAFSSE ERGRELPAAE ELRRRHLARW AEARAVADRL
KALHQEGDRL AASHPESAGE ISSSLHRLDA AWDELQQLAA RRTALLDEAI AEHKFDDTLK
ELEVWVSETV KRMDSAEPPE SVADAEALLE VHHERKAEID GRQKAIASLQ KEAESAGRPE
RIQRVATLAD SLDQAWLQRK QYLTQAHELQ LFKEQAQQTE DWLASKEAFL NNDDLGDNLD
AVETLIRKHA EFAKLVESQV GRVAEVQRFA AGLLQRDHYD AAYIQRRVQH LLDRAQRLKE
RCDERESKLQ QARQLQEFRR NLAHEREWIE LKMQIANDQS YRELSNLQSK IQKQAAFESE
LAANKKRIDD VANTGEELIE EKHYASQEIA KHVEDLENLW RELQAAAKLR RERLQEAYQA
RVYLRGLDDF TAWLDDVEAQ LLSEDHGKDL TSVTALLKRH TRLEQQCASK ADTAAQLADT
AHQLARNGHF MAEDILERAE RAVTRYKQLQ EPMQIRRDNL EDAALLHRWD RDADEEFDWL
RERGAELESD APLGDSLPEA QALLKKHLAL EAELLAREPS IKALSGRAST LSRRGHFAGA
ALERRAAELS QRLRCVVEAA GARACSLRAR ADLLALLAEG AEAAAWLAAR RAPLAAPDVG
RDEEDVLALT RRLEAQIREL ATFDSTLARL EKTAAQTDRS PADAETVRTM LQELQSAYEE
LKLLAARRQQ RLQQSLKYFK FVQECSEAQE WIGEQMATAA SEDYGLDVEH VDTLQQAFDN
FLTQLHANEG RIEAVCEAGG ALLEDNAPEA DRVRQRIDDI RGLWDDLKEL AVARQEALAG
ARQVHEFDRR AEETGAWIAE KEAALQLHRQ LHQLRALRAD LLAIQDAHKE LKQEAERLGA
AFPDAREHVS AKLEEVSEAL GALEAHAAHS EQQLALADHL QAYFQTYQDL LAWTNEMIAR
VTAPELAGDV AGGERLLARH RDMRAEIDAK EDAFHTLYSD GEKLVREGHF MANEIEERVS
TLRSRQGALE AAWRARATVY ERHLDALIFL RDADSLEHWI LTRMPLVRDG KYGSSVAQTE
ELINRHRDLE ETIESQKDKF NALKRITLRY RHPFHYLAWR ARATVYERHL DALIFLRDAD
SLEHWILTRM PLVRDGKYGS SVAQTEELIN RHRDLEETIE SQKDKFNALK RITLIEQAFS
EQQAEEEAAR RRYAEKQEAE RLQQYRRREM DRIAEERRRD TAPPPQTTPT THTPTAPLQP
TREVERVVAT GSANTMGPAK AASSEENVSA PLDRPQRTDT HVKRAESMSV VKTPKRTPSF
TTRRRTQSFR RHRHDMDELP PVEIEGYLER KQEAGCGGVR ATVRSWRTYY AVLCGQLLCF
FRDQHDFGSA KAAAPPVAIL NARCEAASDY TKRANVFRLS CGDGAEYLFA CASPQLLAEW
VAKLAFHAHL PPELQLTPYS EASAAATATT TTTTGVTTDE LRRRLHENAS SSSSAASSPE
PRRAGRSQAE ILQEHRNSQQ EQRNSQKRAS ATPDRHIESA VLPSLPPRQP PAQPPQTSHE
EPADVVLRNV SERSGSPWGR SRFSNGRDLN AEFLRSQREA ESGAPPLPAS VPPLPDRAPP
LPDRGPNLPE RVSMIAERGL LDKNPQQSVT ALVNSYQQKM TRSWQEKDQN RNPTWQGQGQ
GQNNNWQTVE TTSHFYSASE LAYGEGSAGA GAGAGGTRPA SVAGSGGSPA LDQRPASRSS
GESELSVGGV SKDKKDKKGV FGGLFSRKKR PQSHMYLY
//
