ID   A0A0N4T3H6_BRUPA        Unreviewed;       825 AA.
AC   A0A0N4T3H6;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Protein SDA1 {ECO:0000256|RuleBase:RU365057};
GN   ORFNames=BPAG_LOCUS2726 {ECO:0000313|EMBL:VDN83912.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000275601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0000275601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN83912.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC       cytoplasm. {ECO:0000256|RuleBase:RU365057}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|RuleBase:RU365057}.
CC   -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000256|ARBA:ARBA00005783,
CC       ECO:0000256|RuleBase:RU365057}.
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DR   EMBL; UZAD01000483; VDN83912.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4T3H6; -.
DR   STRING; 6280.A0A0N4T3H6; -.
DR   WBParaSite; BPAG_0000275601-mRNA-1; BPAG_0000275601-mRNA-1; BPAG_0000275601.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:UniProtKB-UniRule.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027312; Sda1.
DR   InterPro; IPR048292; SDA1_C.
DR   InterPro; IPR007949; SDA1_MD.
DR   InterPro; IPR012977; SDA1_N.
DR   PANTHER; PTHR12730; HSDA/SDA1-RELATED; 1.
DR   PANTHER; PTHR12730:SF0; PROTEIN SDA1 HOMOLOG; 1.
DR   Pfam; PF21638; SDA1_C; 1.
DR   Pfam; PF05285; SDA1_dom; 1.
DR   Pfam; PF08158; SDA1_HEAT; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365057};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU365057};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW   ECO:0000256|RuleBase:RU365057};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365057}.
FT   DOMAIN          145..520
FT                   /note="SDA1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08158"
FT   DOMAIN          581..760
FT                   /note="SDA1 middle"
FT                   /evidence="ECO:0000259|Pfam:PF05285"
FT   DOMAIN          778..820
FT                   /note="SDA1 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21638"
FT   REGION          749..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        749..769
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   825 AA;  95456 MW;  E51145B11CB6DDE9 CRC64;
     PLCDTQHTHT HFQWNARRRC SPTINHQVIF NLSPISCEVP FGPLFSIWVS YATGRADEGT
     NASIPLACIG VMATHLETNL GLLQELVPLF SLFEAFLVII NKDPESYKEE FLAEYNFYIK
     TIQLLRLQPS LNHADLQSLL ELINFLASAS SHYPKEGAEY AASIMEILNS RLTGLDPEIR
     VAFCKALVIL RNRRIVDPLA VMDLFFTLVP CEDKNLRKFI CGSIKALIKK LTLQYRDQKM
     LSKVRTFLFT KLKDSRSIVV RTAELVLVDG FRKGFLKDAK TANALAECCL HKISRIQIAA
     IRFFLGSMED NDSDDDESAS EEDQKTLKEV NTKNSFQVVV AYKAAKKTRK KKERYMKAKK
     LLSKGKKSKN ENAGKFCNLL AIRYIYDPQT FAERLFGLLE SRKNEKFETR LLCMALCARL
     IGTHRLQALS FYSYMHRFLQ PKQREITRIL LYVAQACHEL VPPDIIEQLV YVIAQNFVSD
     RNTPEAVTVG LNTIREIFAN CPFAATEDLL RDLTDYKRFK NKNVSMAARG IITLFRAVNP
     KLLHRKDRGR PTQKLKDLKV AEFGVEYAKE FVEGAECLPV EADAIDRELD DESDDTDFDS
     DFDTEFVEHD SLDSDVNMDS CGNHIVVTDI CVNNAKSPNK ESLETNDQKI TFSETKKKAR
     RVCETRILTQ NDFRKINAFR LKQQVGYDGK RRNDDIKLEE ELGEIIARQF FIIYVWRILK
     NFHLWHNEEN GLTRLKDIEK FHKKLRKETK EERMETVKKG REGRQQFGKP KKAGPHVGRT
     NRELMKRKNF QMVRHKLRGK NRQRSFKERQ ESLRKYLLRQ AGRKI
//