ID A0A0N4TAK8_BRUPA Unreviewed; 361 AA.
AC A0A0N4TAK8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Calpain catalytic domain-containing protein {ECO:0000313|WBParaSite:BPAG_0000524501-mRNA-1};
GN ORFNames=BPAG_LOCUS5208 {ECO:0000313|EMBL:VDN86394.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000524501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000524501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN86394.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; UZAD01003403; VDN86394.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4TAK8; -.
DR STRING; 6280.A0A0N4TAK8; -.
DR WBParaSite; BPAG_0000524501-mRNA-1; BPAG_0000524501-mRNA-1; BPAG_0000524501.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 73..361
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 128
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 285
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 309
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 361 AA; 41498 MW; 888528EC8139791C CRC64;
GKDNKLGAVG KIVLDNIISG KFKRKVDPYI PPEPSRHLRP PVPDRRADEA LHFYAERDRC
LAVGLLFFSM RQLFEDPQFP ANDKSLFFSR RPPKQIEWRR PGEICEDPQL LYEGHSRFDV
VQGELGDCWL LAAAANLTLK DELFYRVVPP DQSFTENYAG IFHFQFWHYG AWVDVVIDDR
LPTSTSGELL YMHSRDNNEF WSALLEKAYA KLHGSYEALK GGTTSEALED FTGGLTEFFD
LTQPPKHLME MMMRGFEMGS LFGCSIEADP NEWEARMHNG LVKGHAYSIT GMKMVNGPRG
SIPLLRIRNP WGNEQEWNGA WSDNSAEWRS ISQEQRDEMG LVFAHDGEFW FVVMLFYHSD
S
//
