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Database: UniProt
Entry: A0A0N4TKM7_BRUPA
LinkDB: A0A0N4TKM7_BRUPA
Original site: A0A0N4TKM7_BRUPA 
ID   A0A0N4TKM7_BRUPA        Unreviewed;       916 AA.
AC   A0A0N4TKM7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   12-APR-2017, entry version 6.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000890201-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000890201-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:BPAG_0000890201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; BPAG_0000890201-mRNA-1; BPAG_0000890201-mRNA-1; BPAG_0000890201.
DR   Proteomes; UP000038020; Genome Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038020};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038020};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    416    440       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    461    479       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    559    580       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    592    617       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    623    646       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    699    718       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    856    880       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       97    124       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   916 AA;  105874 MW;  F881AF6412D7F73D CRC64;
     MGSLYRSEQM RFCQMIVQKD AAFSCVAELG KHPYVQFKDL NANVNPFQKM YLRDIQRFEE
     LERKLRFLDA QIRKDDIEVN DDVGGDDTYE VLAPHELNQL EGTLIDLERD VINMNENNII
     LKRNYFELKE WEAILEKTDH FFEEGISDVA MHEIEAMQED PALVLRSGKE PIGFLAGVVN
     RDRVNAFEKV LWRACHKTAF IRTTDIEEEL ENPDSGEICS KSVFLIFYKG DRLRIIIEKV
     CEGFKAKLYN NCPKNSKDRH AAARDVKARI SDMRTVLGQT QEHRYKVLQA ASNSVRQWQK
     EVRMQKSVYY TLNLFTFDAI GKFFVAECWV PYVDLENVRL ALEEGVRKSG SSVRPVLNLL
     ETTEEPPTYN RVNKFTRVFQ AIVDSYGTAS YLEINPAICT NLTPISAPYT IITFPFIFSC
     MFGDLGHGII MLLVGLWMVL REKNLAARNI KDEIFNMFYG GRYIILLMGI FSIYAGFLYN
     DLFAKSFNLF GSKWRNPFPN AEIESWDSQS ILMHKEIMID LPPSRSYMHD SGPYWFGVDP
     VWNLAENRLN FSNSLKMKLS VILGIAQMTF GVFLSLLNYI YFKSKIEICT VFIPQILFML
     CIFIYLCVQI IIKWLFFWVQ EEYIFGLLYP GSNCAPSLLI GLINMFMFKY RRLGFLNESK
     IVSQNDGHVT YENWPDCYLS QWYPGQASIF LTMLKFQSTL EAILVIIAVI CVPVMLFGKP
     IHFLLHRKKR NVISDNAVIW MNQESEKAEI TLNENGSGLN KKDWEETISD NECEEEVTAF
     SYSKFYFESF GDVMVHQAIH TIEYVLGCVS HTASYLRLWA LSLAHAQLSE VLWEMVLVQA
     FSISGIAGYI AAYLVFFAFG VLTVSILVLM EGLSAFLHAL RLHWVEFQSK FYLGLGYPFL
     PFYFKDVLLK ANVVEK
//
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