ID A0A0N4U2B7_DRAME Unreviewed; 432 AA.
AC A0A0N4U2B7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Exosome complex component RRP45 {ECO:0000256|ARBA:ARBA00019572};
DE AltName: Full=Exosome component 9 {ECO:0000256|ARBA:ARBA00032660};
GN ORFNames=DME_LOCUS5169 {ECO:0000313|EMBL:VDN55196.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000080901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000080901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN55196.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC subunits. {ECO:0000256|ARBA:ARBA00011695}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYYG01001151; VDN55196.1; -; Genomic_DNA.
DR STRING; 318479.A0A0N4U2B7; -.
DR WBParaSite; DME_0000080901-mRNA-1; DME_0000080901-mRNA-1; DME_0000080901.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd11368; RNase_PH_RRP45; 1.
DR Gene3D; 1.10.287.370; -; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR009053; Prefoldin.
DR InterPro; IPR004127; Prefoldin_subunit_alpha.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR033100; Rrp45.
DR PANTHER; PTHR11097:SF14; EXOSOME COMPLEX COMPONENT RRP45; 1.
DR PANTHER; PTHR11097; EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN; 1.
DR Pfam; PF02996; Prefoldin; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT DOMAIN 113..223
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 249..316
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF03725"
SQ SEQUENCE 432 AA; 48671 MW; AB245AE2AD69FAFA CRC64;
MYISAQMEDP AKFMIDIGTG YFVEMSNEQA ADYFKRKQQY LKKQMETIEK ILPEKQQVRN
IIMENLKKKI QLLCAHMPAV SELMVVNVMN FAALKLFLVQ SWEHVLQLLD IRNKIFVQIS
CNLTEPTSAR GNMGSVEVHV RMSPMAAPTY EDGKLGSKGI ELMRVLEILL RDCGVIDLES
LCIRKYKQIW SIRVDVHILD DDGSLIDCAS VAVLTALVHF KRPDVNVLSD SVIIYGSSQK
MPIPLNIYHL PICVSFGVYD DTQPAVLDPT DREEMCLKGT LIVAVNKRHE ICTLHQTGNL
VLNQDLIMQC VETAMQRAIN VSELISSVIT DDNLKSGLVS LNILSSHQCE PNELIAPAVK
NHALIIGERD DKVLIEEDLI QIGSEDQELI EQIAEITVSQ KILDQSYKGR TEMDDVNDLL
DSIEENFANS HS
//
