ID   A0A0N4U3R8_DRAME        Unreviewed;       730 AA.
AC   A0A0N4U3R8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=DNA mismatch repair protein Msh2 {ECO:0000313|WBParaSite:DME_0000137901-mRNA-1};
GN   ORFNames=DME_LOCUS5739 {ECO:0000313|EMBL:VDN55766.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000137901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000137901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN55766.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|ARBA:ARBA00006271}.
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DR   EMBL; UYYG01001153; VDN55766.1; -; Genomic_DNA.
DR   STRING; 318479.A0A0N4U3R8; -.
DR   WBParaSite; DME_0000137901-mRNA-1; DME_0000137901-mRNA-1; DME_0000137901.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT   DOMAIN          315..639
FT                   /note="DNA mismatch repair protein MutS core"
FT                   /evidence="ECO:0000259|SMART:SM00533"
FT   DOMAIN          658..730
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|SMART:SM00534"
FT   COILED          543..570
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   730 AA;  83729 MW;  AC2D2198CFD46CF4 CRC64;
     MDSIDKSLLK ILQNKASGTV AIFEKIDFYC CYEEDAFLVA NEIFLSEIGL RRITIDTQEL
     TYHNLNNGQY NRVVRDLLLL LHYRLEVYAL DDRQWKLKAK VLFDSNLCIK GSLGCLGDFE
     EMIGDSIEIN ELSTVMALVL SEEHGSDEYR LSIGFCNVRD VRMTVAEFSD TQHFSNLEKC
     IVSLTPREFI IVPNISKTMV DRSDMEIWID HLEIALKRAG VKRVPFQSWE NVTVEMENKL
     FQVINTKFKD IHLSEQQKRC LISLVEYLHI ADDATYYDCF QLFNYKSAGH MYLNMAAVRA
     LELFSVSYDE DASFGDTGTL FQLMNKCRTQ HGQRLLRHWM RRPQYDLRRI NERLDIVEAL
     YSNFTCRAIL YDNILRRVPD VTGLTRKLMM KKAGLQDCYR LYQLIRLLRR LEEVLTDLYA
     NSNNLAPSIN DLCLEQIRVA LLQFEKFARL IETTIDVEYC EQTGTYRIKP EIDEYLLHTA
     KRMKAIESDC KNLFNKACAK IPEAVKLDYN SQYGFFFRVT LKAEKSLRQM GFRILATSKG
     SGVRFTNSDL DRLNSEYREL EKIYESSQTE LIKMVVNTCA SYVPALNQLS ETLAILDVLV
     AFSVLAATSP SKYTRPQLLD KDSSVIELKS CRHPVLESIL NASSFISNDV IMGKDPEGAN
     MGGKSTYMRS CALTVLMAQI GSFVPCDSAR FSLMDGIHTR IGSCDYQCRG ISTFMAEMID
     SASILEQSTV
//