ID   A0A0N4U675_DRAME        Unreviewed;      1034 AA.
AC   A0A0N4U675;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE            EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN   ORFNames=DME_LOCUS6763 {ECO:0000313|EMBL:VDN56790.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000240301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000240301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN56790.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   EMBL; UYYG01001157; VDN56790.1; -; Genomic_DNA.
DR   STRING; 318479.A0A0N4U675; -.
DR   WBParaSite; DME_0000240301-mRNA-1; DME_0000240301-mRNA-1; DME_0000240301.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT   DOMAIN          523..598
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1034 AA;  118545 MW;  E29028F150A1F0E6 CRC64;
     MVSHYEYVAP IFKNERTTFE RIEKFISNDY FADCNLRGRL YRFPRAVSIK HYSSEEVSTI
     SFNDAVQFLS SKGKQVDIGF SFGPTWTIHW FEVICEVPRE WESENLVLQF DAGCEALVWD
     SNGKVIQGCS PDFGRIDIAI PSGQLTHKFY IEASANERNG DGDGGAIRPA KLNKFFELKK
     ACICIFRPDI YDLLINFEIL LEMAEHLPKD GLRRYEALYT ANDMINQLVL FDFSSDIIQK
     CHEKAMKFFA QPNAPSQITL YAIGNCHIDT AWLWSFDETK RKCARSWSSV LSLMKKYPEM
     NFAVSQAQQL LWLSEEYPSI YEDIKDLSLD GQFIPVGGSW VEMDANIPNG ESLLRQIIYG
     QKEFRKIFKS LSNIFWLPDT FGFCAQLPQI IKHCGMSYFV TQKMSWSLVN KFPHNSFRWI
     GIDGSEVLAH FPPHHYVAKI TAKECLESAR NFLDKGRSKI AMMLYGHGDG GGGPDEYMLK
     RAERLVDCDG IPKILNGTPN DFFHELEKDL PNLCTWKGEL YLELHNATYT THSILKKMNR
     KLESLLRDHE FLQTLLLVEE GRFTSLENAW KNVLLNQFHD ILPGTCIKEV VADAVRIYNC
     CFDRLAVHDG SVLKMIDTVK QESSDNWFLN SCTWTRTFCH DGQLYNISPL SVFHLNSLHS
     VPFNYNKRLA TVDENNFKLN NAFLSATFDK LGRIMNLVIY SNENSVNKTF NVINPGELAN
     QFLVYDDVPL FWDAWDVMDY HLETKKEIAE GVSAAIVENS DFYAVIHFEL KISPKSYIIQ
     KVSLRADLPY IVFDTTVEFP VNINNSEALY EIPFGFIGRT TTKNTTWDSG KYEVCAHKWM
     VLSEYNRGVA ILNDCKYGHS CEGNVMRLSL LRSSKSPDDE ADMGDHKFSY ALYPFIGQLQ
     QPYNNTKLNI VRAAFEFNNP IRRIQNWTVG RDVTNVLSVE GDEGIFLSSI KPAEIEPNAF
     IIRLFESFGG AASIKLFVKH ARIVSVDLCD ALEQSISNIP IEMELHEESH SSEYISLEFR
     AFEIKTLLVR LYAV
//