ID   A0A0N4U7L3_DRAME        Unreviewed;       538 AA.
AC   A0A0N4U7L3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000256|ARBA:ARBA00015407, ECO:0000256|PIRNR:PIRNR039099};
GN   ORFNames=DME_LOCUS7140 {ECO:0000313|EMBL:VDN57167.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000298101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000298101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN57167.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein neddylation.
CC       {ECO:0000256|ARBA:ARBA00005032, ECO:0000256|PIRNR:PIRNR039099}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006868,
CC       ECO:0000256|PIRNR:PIRNR039099}.
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DR   EMBL; UYYG01001159; VDN57167.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4U7L3; -.
DR   STRING; 318479.A0A0N4U7L3; -.
DR   WBParaSite; DME_0000298101-mRNA-1; DME_0000298101-mRNA-1; DME_0000298101.
DR   UniPathway; UPA00885; -.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR030667; APP-BP1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   PIRSF; PIRSF039099; APP-BP1; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR039099}.
FT   DOMAIN          8..534
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
SQ   SEQUENCE   538 AA;  61645 MW;  F7EEE69B46B2F910 CRC64;
     MKEDEIRYDR QLRLWGDEGQ HSIAQADICV FGSSALACEI LKSLVLAGIR SFLIVDSEVV
     TNPDLGSNFF IEKTDLMQPR AKIAELNPSV EGKFDLRSAE QYISQNSDSL SEFSVVIASN
     LLQRTAYKIN KYLFIKNIPF IYARSYGLVG FVRISVKEHT VTDCHDENPL PDLRIDEPFE
     ELASFSDEID LGSLKYDEHS HIPYLILYIK ALKVWREKQD QKHAFPDTYE KRKDFEQVYL
     SLRKPKAEGN LHDEENFSEG RAAIIRSLHK TCTPKKTQEL LEHPKAVDPD HSQFWIHVAA
     LRRFVLQHNK LPLSGQLPDM ISDTKTYVRL ASIFRQKAIC DAKEVYRNVC SILNEKGYSQ
     EFFKFNDCKQ FCKKASMIRV INGSLIESET NMEYPECLIE NIRNSNFSRH HISNVLCIPP
     VLWYLLIKAV DRFQMEKSRF PGTNGVPCII DSHDLKQRFS AILQSSQIID AAEVLEKVPE
     EVVSEMCRYG NAEIHVIAAF IGGIVAQEAI KLITHQYLPL NNMLIFDGHT QQGSIFSL
//