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Database: UniProt
Entry: A0A0N4UI18_DRAME
LinkDB: A0A0N4UI18_DRAME
Original site: A0A0N4UI18_DRAME 
ID   A0A0N4UI18_DRAME        Unreviewed;      4014 AA.
AC   A0A0N4UI18;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   22-NOV-2017, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:DME_0000723101-mRNA-1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000723101-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000723101-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:DME_0000723101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
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DR   WBParaSite; DME_0000723101-mRNA-1; DME_0000723101-mRNA-1; DME_0000723101.
DR   Proteomes; UP000038040; Genome Assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 5.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038040};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038040};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3394   3413       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3568   3585       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3627   3649       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3766   3788       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3808   3833       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3854   3873       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3893   3912       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     59       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      243    453       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3149   3184       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     3187   3219       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    3162   3173       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    3197   3208       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   4014 AA;  456529 MW;  C2922B9D07705169 CRC64;
     LDLNDRTIAF SLNGELLLVN DPSGSEVAFD NVISGDGFVP AMTLGAGQKA RLNFGQDSNT
     LKYFTTCGLQ EGYEPFCLFC SNMYRQMPMW YAKSLPLFTD IDAGSTVEVY RIPATGNSPP
     CLKISQKIDT SDTSSMEKAK MEYIRLSLPV RCHKTFSKVR NKEAIMQAIR DIQERMAHEK
     IGMPSIRPIT IPKEFEDSRY AQTKKTHGKS LLNTFKRSTE DEDAESSRSK PISLDETHDL
     VERPGLGQEG HKKKEIEKKS SEPSGIARST SSFDGTSDEA LNVATTPLKD LFRMVLWFQR
     YKNMICSFQI DEFYYAIRIF PGQDPANVWV GWVTPKFHYY SASFNLGESV RRCKFQYAAN
     DDPADDSLEY RNCYVMNAAE LLQAVPDAAN TKVTGLLIGC IIDTSIGELS FLAAGQDTGI
     RFQLDPGAML YPAAFVAPTT TEILQFELGR IKYTFPLSSA MFKSSQKSLI PFCPPRLTVE
     KIQPVHWARV PNECLRTTAL KLSDIRGWSI LCDDPLQMMT IYVPEKDMSY DILELIEHND
     CLTFHRQTLN LYCKLASFGN QKVAHILCSH VDEDQIMYAI KSHYLSGPMR QGFHDFLIAV
     HLKTHVDACM AGAHEYVVPL IKELEMKNVF SSEAEDRFPL IYGRCVSIRP TMASCVVRTD
     FKNDTDTKLL APTFNFEALK SHVTSSLISA TEHAVMNCRD LIGGCNSSHF EPLFKLFNSL
     LVINLIDDED LKDVLKLIHP SAFDETYAPG NYFFLGSARK GLTEIWLDES VKIQFVEILD
     NICDIQLRHR VESLIAFAVG FVSDLQQDQC KRYMEIKQTD MPPAEAAKRT KEFRCPPKEQ
     MFRLIKCKHS DSGAGIMLDD EVEYDQCPMD ESLQEQLRIE SLEHPGNLPP SSSYSLAKGL
     YPKSQWGELN QNKNTILEKI TCVGALSEHC SGVDVRGILE FTCKGLAWRI VLSISSVSVA
     DGEFCALLVS KIRCIKNTDD EISEDMIPLD DQNSWVDQLA QLVINVPPPP FQKDDRIEHM
     GSENFRRMVC NMLKSWATSS TIESQILIRK MFALLLRQYN GVGEIITALS QTYVLHERNI
     EDVKDFIEHL IQVHEDVMTI MMNVLTAQQG TVEHSDRDTS EENLANKTDR QLNASEMVVA
     CSRFLCYFCR TSRQNQKAMF EHLSFLLDNA TMLLARPSLR GSVPLDVAYS SFMDNNELAL
     ALKEEELDKL TVYLSRCGLQ SNSELVAKGY PDIGWDPVEG ERYLDFLRFC VWINGESVEE
     NANLVIRLLI RRPECLGVAL KGEGQGLFSA FKVKEAIALS EDIHALEDGD DPQLLSSAVL
     RQQQHYPSKE AEGEDYIDLG AATLDFYSSL VDLLAKCAPD RLTIQAGKGD SVRARAILRS
     LIPLDDLGQI LSLRFTIPNL MAQNSADEGD KSKLIRRQSS GAHTILSNDL TNIIAVSDAI
     MLHSEMDDKF MDTNNELGSD NSTAFLSADG NTPRMANTRF RLLRSSKIAS PDSNKLDQKS
     LTDVANYNNS KMILDPGPRP GFLPNHKQSV LLFLDRVYGI DSQEMLFHFL EKSFLPDLRA
     STMMDSPKAV ESDTALALNR YLCNAVLPLL TNHSSFFSDA EHHAALLDAT LHTVYRMNRL
     KSLTKNQRDA VSDFLAAITR ELPPSMMVKL MRKVIIDVQE MIEHFIVPLR IMTLHYERCT
     KYYGSGNAYG VASETEKRLS MLLFYAIFDA LGSIPYDPDL FGKALPCLTA IGSAISPDYT
     LTTGGEDAEI IKIRNDQGLW TPKVVDVSNF ELSGMLSNIT TQFAEHFHDS WASRKIEKGW
     VYGDLYSRQS LTHPRLKPFC LLKEFEKSFY KERCSECLRA LLAWNYTIEL VDRDAAEKAE
     QNHSSSGNSI QNFNPRPVDL SNMTLEKDMM NVAEKMAEHS HNIWAKRVFS DLKTKGGNMP
     AQLVPWDLLT DYERRKDRFR AVEILKFLQY HGYRVSSSQN VEPAAERVKA ESERGSVEKR
     FAYNLLEKLT QYLEQASVKM KTIKPSQELS RRNSFQKEGH DVKFFEKVVL HLIHAYFNAH
     RNYFLASSSI VQTGMASNKE KEMVANLFCR LAFLLRIKNH AFGSVAKVAV RCLQVLTRAL
     DLRTLVKINS DIVRTSLLTF FNNCADDLYL AVKELQNGGQ YSLLRGENLT SWMSLEFANQ
     VNIPVLTTMF FHLSANHFGT DLLLDDIQAA CYKILDSAYL LNGLGSEPPQ VHHRKSIAYE
     TEKHRPALGQ CLSAFASCFP IAFLEAEFNK YNKYSVLAKT QDQSVQVQEM LQNLAAHIPK
     LEKLLADIEE VSTNGVMYKD QPNIYDVDLP LICAYLTYWW QLGPDGTGKT SQLTTSVTSD
     HINRVFCALL TLICNHVGVE NASWLCRINT FSVQVVQYVS CDPIKDYMLP VAERLRRLAE
     KAFKDEEHMR THPDDADEGT VVEDNARLVR DVYAFFPILM KYCDLHRAQW LKTPSWETDG
     IYENVAVIFK IWSLSQHFKR EELNFMAQYE GESFSAATGE MKTGKAAIAE RKKKRREGQV
     RKDKHANSII IACLKRLLPV GLNVFGGREL DIVQQTKEKF LAKENEDKIR EFVRSLLEIP
     VKTDPTDKNA WQLSLYRKIG KSQMRGNEAM TQDAIVEKIT NMGQVVAILH ITEHSSTSLK
     SAWKTMLSTQ RKRAVVACFR MIPLHSVPRL DHLKRMNVKF RVTSKLEKED RWKKVISLQR
     KRLAISLITA SHLYRVDKHR AVNYFLPAFS KLWLEDDNIG QDALITEITN TEDEEDVPHT
     NLDDELFSED FRDDKNAVTR ADPLKQLIQC FQRAATSEQS QVASIANDTL FVNFARVMSK
     SIHIEDEDGD GDDEGELDQA QKEEISQALR AEQAILADRG AAIMCLMYLS ASNGEPSEMV
     AETLQLGIHL LSGGNIHIQK LLIEYLQLKK DVRFFTSLAG LMNKCSVLNL EMFERQIKAE
     GLGMRAELAA GGNQNLNDAD FTCSLFRFLQ LTCEGHNLEF QNYLRTQPGH TTSINLINST
     VDYLLRLQES VMDFYWHYSS KEVIDEGGKE YFLRAIRVCS QVFNTLTESI QGPCVGNQMT
     LANSRLWDAI NGFFFLFAHM MEKLYKNSTQ LELLREFLNL QKDMIVLMLS MLEGNVLNGP
     IGKQMVDALV ESQQCVEMIL KFSDMFLKLK DLTTSQAFQD FDTNRDGWIS PKEFQRAMES
     QKMYSVEEIT YLMMCTDVNN DGKVDYMEFT ERFHNPARDI GFNLAVLLIN LKEHITNDPR
     LEKIIEKAST LLEYFDPFLG RIEIMGSSKR VEKIYFEIQE SWLEQWSKQQ IRDSKNSFLF
     NVLQDDGGDQ GKLEAFINFC EDTIFEMQHA AEISAGDSAD SKMERALKQR EYFLQQTSAG
     AQISATFKTG FNYGLNAATA LKPSHMIFKS SQKIALFLYL VICTLFRFGY YLMTPEKDDE
     TGQTPLPIAE SMTTRFQTVH PNDIPSFRYH HHHDFDVFGV HLHTDDTVVP PTPTFGDVTS
     APNFPTAATE TVKVQTTAAA PASPSIYEAQ SVVGSGQYGI VASHAASEFS ETSGYYEPKI
     AEQSLIRNKG SILNVLARNF KTIEKTTLYL AFFINVILLF HRVNITSGSA ADNNGGEEEE
     GKETVYITGM VVPYIAYEIT GWTLSQLLYW ISVLHALASF ALLVSFYQLK VIPLITFKRE
     KEVARRLMFD GCWITEEDEE ERSLVDSVMW YLDRIVISSK SFPMKYWDKF VRRKTRQKFR
     EQIDEETLNA ILGEDKSAGD NSFDYRYTCW LWLGVILTNG QFLYRVNYLF CSACGVFFSP
     FFYAFHLIDV VLSFPMLKAI LQSVTHNLQQ LILTIMMTLV VVYLYTVVAF NFFRKFYIQE
     GEEGEEPDRK CHNMLTCFIF HFYAGVRAGG GIGDELESPY GDDLEYPRML YDISFFFFVI
     VILLAIMQGL IIDAFGELRD QQESATEKLE SSCFICDIGK ETFDRMPRGF EIHTTKEHNF
     ANYLFFLQHL VNKDETEYTG QETYVREKYD NRDWEFFPVG ECFVKQYEDQ LLQS
//
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