ID A0A0N4UM69_DRAME Unreviewed; 612 AA.
AC A0A0N4UM69;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Histone acetyltransferase {ECO:0000256|RuleBase:RU361211};
DE EC=2.3.1.48 {ECO:0000256|RuleBase:RU361211};
GN ORFNames=DME_LOCUS2774 {ECO:0000313|EMBL:VDN52801.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000892801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000892801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN52801.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|RuleBase:RU361211};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361211}.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|RuleBase:RU361211}.
CC -!- SIMILARITY: Belongs to the PUR DNA-binding protein family.
CC {ECO:0000256|ARBA:ARBA00009251}.
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DR EMBL; UYYG01000079; VDN52801.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4UM69; -.
DR STRING; 318479.A0A0N4UM69; -.
DR WBParaSite; DME_0000892801-mRNA-1; DME_0000892801-mRNA-1; DME_0000892801.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032422; F:purine-rich negative regulatory element binding; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.10.450.700; -; 1.
DR Gene3D; 3.30.2450.30; -; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR006628; PUR-bd_fam.
DR InterPro; IPR025995; Tudor-knot.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF161; HISTONE ACETYLTRANSFERASE KAT5; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF04845; PurA; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SMART; SM00298; CHROMO; 1.
DR SMART; SM00712; PUR; 3.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361211};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 410..612
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT ACT_SITE 586
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 612 AA; 70340 MW; 00C54C27EA44840A CRC64;
MSDASSEEHQ QMPSEQELAT EMLEVQRKRF YVDVKQNSRG RFIKLAERVP PFKVGLGGRK
SRIILSMAAA VEFRDHLDKF VKFFDGLASG EEQAVPSQNG QLRSEMIVYR SRRYFLDLRE
NQRGKYLRVS QMVYRGPPGI RSQIALPAPG MAQLRDTLTV FIDKFGEGYL YKNNENVDVP
DSKQLRAENN KFFYFHVGHN DRGTFVRISE VKQISGLRNS ITVPQSSWGD FRDLLGELME
KMAATKVDEG YLMDSEGKWS VESLVDGARL AVKMSGTNDY REAEILTIRP GERGYRFYVH
YIDCNRRLDE WVEESALDLT NVRFPQKGSK IQKTQIETSN SRASSAERDM ANKKGATRKR
KILVEIEPPK VDDQPIRTSS PSLPISISDI RAPSQRGSMS VVGHSEDALM RIRNIEMIEL
GRYRMQPWYF SPYPQELTSL SCILLCEFCL KFFKSVTCLK RHMTKCNLKH PPGNEIYRSD
SLSFFEIDGR KNKIYAQNLC LLAKLFLDHK TLYYDTDPFL FYVMTEQDDR GFHIVGYFSK
EKESAEEYNV ACILVLPPYQ KKGYGRLLIE FSYELSKCEG KTGSPEKPLS DLGLHVRTVN
ASDTWTEVNA TM
//