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Database: UniProt
Entry: A0A0N4UM69_DRAME
LinkDB: A0A0N4UM69_DRAME
Original site: A0A0N4UM69_DRAME 
ID   A0A0N4UM69_DRAME        Unreviewed;       612 AA.
AC   A0A0N4UM69;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Histone acetyltransferase {ECO:0000256|RuleBase:RU361211};
DE            EC=2.3.1.48 {ECO:0000256|RuleBase:RU361211};
GN   ORFNames=DME_LOCUS2774 {ECO:0000313|EMBL:VDN52801.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000892801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000892801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN52801.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC         lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC         Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC         Evidence={ECO:0000256|RuleBase:RU361211};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU361211}.
CC   -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC       {ECO:0000256|RuleBase:RU361211}.
CC   -!- SIMILARITY: Belongs to the PUR DNA-binding protein family.
CC       {ECO:0000256|ARBA:ARBA00009251}.
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DR   EMBL; UYYG01000079; VDN52801.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4UM69; -.
DR   STRING; 318479.A0A0N4UM69; -.
DR   WBParaSite; DME_0000892801-mRNA-1; DME_0000892801-mRNA-1; DME_0000892801.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032422; F:purine-rich negative regulatory element binding; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd04301; NAT_SF; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 3.10.450.700; -; 1.
DR   Gene3D; 3.30.2450.30; -; 1.
DR   Gene3D; 3.40.630.30; -; 1.
DR   Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR002717; HAT_MYST-type.
DR   InterPro; IPR006628; PUR-bd_fam.
DR   InterPro; IPR025995; Tudor-knot.
DR   InterPro; IPR040706; Zf-MYST.
DR   PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR10615:SF161; HISTONE ACETYLTRANSFERASE KAT5; 1.
DR   Pfam; PF01853; MOZ_SAS; 1.
DR   Pfam; PF04845; PurA; 1.
DR   Pfam; PF11717; Tudor-knot; 1.
DR   Pfam; PF17772; zf-MYST; 1.
DR   SMART; SM00298; CHROMO; 1.
DR   SMART; SM00712; PUR; 3.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   SUPFAM; SSF54160; Chromo domain-like; 1.
DR   PROSITE; PS51726; MYST_HAT; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361211};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          410..612
FT                   /note="MYST-type HAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51726"
FT   ACT_SITE        586
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ   SEQUENCE   612 AA;  70340 MW;  00C54C27EA44840A CRC64;
     MSDASSEEHQ QMPSEQELAT EMLEVQRKRF YVDVKQNSRG RFIKLAERVP PFKVGLGGRK
     SRIILSMAAA VEFRDHLDKF VKFFDGLASG EEQAVPSQNG QLRSEMIVYR SRRYFLDLRE
     NQRGKYLRVS QMVYRGPPGI RSQIALPAPG MAQLRDTLTV FIDKFGEGYL YKNNENVDVP
     DSKQLRAENN KFFYFHVGHN DRGTFVRISE VKQISGLRNS ITVPQSSWGD FRDLLGELME
     KMAATKVDEG YLMDSEGKWS VESLVDGARL AVKMSGTNDY REAEILTIRP GERGYRFYVH
     YIDCNRRLDE WVEESALDLT NVRFPQKGSK IQKTQIETSN SRASSAERDM ANKKGATRKR
     KILVEIEPPK VDDQPIRTSS PSLPISISDI RAPSQRGSMS VVGHSEDALM RIRNIEMIEL
     GRYRMQPWYF SPYPQELTSL SCILLCEFCL KFFKSVTCLK RHMTKCNLKH PPGNEIYRSD
     SLSFFEIDGR KNKIYAQNLC LLAKLFLDHK TLYYDTDPFL FYVMTEQDDR GFHIVGYFSK
     EKESAEEYNV ACILVLPPYQ KKGYGRLLIE FSYELSKCEG KTGSPEKPLS DLGLHVRTVN
     ASDTWTEVNA TM
//
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