ID A0A0N4UN74_DRAME Unreviewed; 226 AA.
AC A0A0N4UN74;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=TGF_BETA_2 domain-containing protein {ECO:0000313|WBParaSite:DME_0000934201-mRNA-1};
GN ORFNames=DME_LOCUS3064 {ECO:0000313|EMBL:VDN53091.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000934201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000934201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN53091.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; UYYG01000101; VDN53091.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4UN74; -.
DR STRING; 318479.A0A0N4UN74; -.
DR WBParaSite; DME_0000934201-mRNA-1; DME_0000934201-mRNA-1; DME_0000934201.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd08698; TGF_beta_SF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF298; PROTEIN 60A-RELATED; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..226
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033230231"
FT DOMAIN 136..211
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 226 AA; 25811 MW; 697994A0F51F3E6E CRC64;
MQYYKATYFI LFLLVNGEVF DLEDGTTSLY AIKYFMLMKD GPIGRQASRI NQTSYNEYYQ
KVSRNEASNA LREHIAFASA SGDSCKFNEI TIPNCLHFEI PPNTKISTAS LIIVFIEELV
DEYLLIRLID PFKRFDFIVE PEGFLANYCV GECIHFEGDN PEYKSLSDRF TMKLCCVPVK
YESIDVLYML ASKELKRKQI PNLRVAECGC LPLSSAFSAS NLTTII
//
