ID   A0A0N4UPD0_DRAME        Unreviewed;       477 AA.
AC   A0A0N4UPD0;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=HRDC domain-containing protein {ECO:0000313|WBParaSite:DME_0000980801-mRNA-1};
GN   ORFNames=DME_LOCUS3412 {ECO:0000313|EMBL:VDN53439.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000980801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000980801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN53439.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYYG01000131; VDN53439.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4UPD0; -.
DR   STRING; 318479.A0A0N4UPD0; -.
DR   WBParaSite; DME_0000980801-mRNA-1; DME_0000980801-mRNA-1; DME_0000980801.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR045092; Rrp6-like.
DR   PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR   PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT   DOMAIN          304..384
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
SQ   SEQUENCE   477 AA;  55623 MW;  8FC0520938D9C83D CRC64;
     NTVKPQNVYG IKVNNDDAVF VPKLKIKHNS LPLTASNLRV IDEDTEILGI YDQDSFGHPY
     QFEISHLKIP DRQLKSGVIR EPLALSKTDL ILIDTKEKLE TLRDTLCSVE EFAVDLEHNS
     YRSFLGLTCL IQISTRKNDY IIDPFPIWNE VLFSFDSFLN HRNFQVFHGP ELDVLWLQRD
     FGIYVVNMFD THSAMKALNY PRFSLQFLIE SHFDVNIDKQ LQKSDWTMRP LSDAHIEYAR
     KDTHYLLSCY DYLRESLINL EHEMPGILQK TYEDSKNICL LSYSKPKFQR TGFEKLLQGR
     KSINNKQRYA LSALWQWRDT LARLEDESHH YILPNHMLLQ IAEILPREQQ GILACCSPIP
     KLLKQELHTV HRIISAARDL PLKKEETYDV SNYISVTFEK FMSNLNKMTK LKALLGEIHE
     IGMPSSYDNV TMCLINKKLD EWASPFESYL LSLKEDLKNI VSFIILIFSA SFIIFDS
//