ID A0A0N4UZU2_ENTVE Unreviewed; 831 AA.
AC A0A0N4UZU2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
GN ORFNames=EVEC_LOCUS2867 {ECO:0000313|EMBL:VDD87724.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000315901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000315901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD87724.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; UXUI01007463; VDD87724.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4UZU2; -.
DR STRING; 51028.A0A0N4UZU2; -.
DR WBParaSite; EVEC_0000315901-mRNA-1; EVEC_0000315901-mRNA-1; EVEC_0000315901.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00109; Kunitz-type; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..831
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033721062"
FT DOMAIN 7..183
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 183..374
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
FT DOMAIN 619..669
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 831 AA; 93790 MW; 892A4BA09EC210C8 CRC64;
MKLALLLVSI FVQRTAVATE QCNRRLYETN NEKTPGNNGF VIEISSATIA SEDSATSYLP
GDKYTVKLRG WQTKYTVTTF RGFGIYAQFE DNRPAGKFEL FDTDSDARIA PSCRRAGVSH
ANLRPKTSAH VLWRAPFSSD AGCVIFRATV ITSKQTWYAD DGPLTKKFCL QEGYKKVEVV
DDPNVPCCAC DEAKYDLEFT GLWSKETHPK DYPSLEHLTH FTDMLGASHS NNYTMWKFGT
IATDGLKEIA EWGNTYKGEQ EMKANATEIR TLMKIKGLWY PEVQGKTRST FQVNRYHHLV
SLAAMFGPSP DWCVGVSSIN LCLPDCTWAK ERVFELLPFD AGTDNGPSYM SPNNPADPRV
PVHPITTKLD KLSPFYNEES DVIPPLAKLV LTVKEVTKSE CKTIEHYKKI AFNATNTSED
EEYKDRRECM VTTWEPWSLC SATCGKGIRM RSRVYVFPIK AQMFHCHRQV IERQFCNAAI
SECKDSDAFN SKCAVSNWNP WSDCSVTCGE GVRSRTRNFK ETTSDKSICP NVNLTQSEKC
VGENGEDCLV TPDPLCKATL WSEWSPCSAS CGDGVRVRTR LLYYTEHEQR CSHISLIEKD
VCQLQSCRRL LGAHMKEICE EEKLDGQCAG KFPRYWYNSR KKRCERFIYT GCKGNRNQFE
TEEECKRICV PGYEAVNKEI VPGHQLINEF GVEEVEDGGE KVDCVVSEWT PWGNCSVTCG
VGKRHRSRQI EIFPRNGGKA CPEHLVQAVR CELKTCGIQL IDFISTLLGI RTVEKCQLGQ
WSPWSPCPTP CGGGKQHRRR TVIKPRNFVD DGSDPICSAP ETATRFCPVT C
//