ID   A0A0N4V3H9_ENTVE        Unreviewed;       274 AA.
AC   A0A0N4V3H9;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 {ECO:0000256|ARBA:ARBA00040793};
DE   AltName: Full=Metazoan SpoT homolog 1 {ECO:0000256|ARBA:ARBA00041464};
DE   AltName: Full=Penta-phosphate guanosine-3'-pyrophosphohydrolase {ECO:0000256|ARBA:ARBA00041770};
GN   ORFNames=EVEC_LOCUS4317 {ECO:0000313|EMBL:VDD89566.1};
OS   Enterobius vermicularis (Human pinworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX   NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000460901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EVEC_0000460901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDD89566.1, ECO:0000313|Proteomes:UP000274131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ppGpp hydrolyzing enzyme involved in starvation response.
CC       {ECO:0000256|ARBA:ARBA00037781}.
CC   -!- SIMILARITY: Belongs to the MESH1 family.
CC       {ECO:0000256|ARBA:ARBA00038354}.
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DR   EMBL; UXUI01007822; VDD89566.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4V3H9; -.
DR   STRING; 51028.A0A0N4V3H9; -.
DR   WBParaSite; EVEC_0000460901-mRNA-1; EVEC_0000460901-mRNA-1; EVEC_0000460901.
DR   Proteomes; UP000038041; Unplaced.
DR   Proteomes; UP000274131; Unassembled WGS sequence.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   PANTHER; PTHR46246; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR   PANTHER; PTHR46246:SF1; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000274131}.
FT   DOMAIN          89..233
FT                   /note="HD/PDEase"
FT                   /evidence="ECO:0000259|SMART:SM00471"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   274 AA;  31214 MW;  46202000ED675AFB CRC64;
     MAQGGKNFDN TPPPAYDDIY PGKIPSNNIY PGMPEDISKD NIKFDDEKDK NDTDKKKLQL
     SKVEGVAKLM KAIDFAARRH RFQRRKDPEG SPYINHSIGV ANILASEGHI LDVDILAASV
     LHDIVENTKT TPEEIEELFG RRSVFLIFLL LEVRGVVSEC TLNKQSASDR RKVQMERAPQ
     LSREVSSIRF FQAVECSSRM DFCIYESFGF KAKLVILADK LHNLRDAERS LPVGWTPHYR
     KDVFKWTKEY IALLKGTNEH LEMALDDVIN RNSG
//