ID A0A0N4V664_ENTVE Unreviewed; 602 AA.
AC A0A0N4V664;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Sulfatase domain-containing protein {ECO:0000313|WBParaSite:EVEC_0000573801-mRNA-1};
GN ORFNames=EVEC_LOCUS5349 {ECO:0000313|EMBL:VDD90598.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000573801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000573801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD90598.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- PTM: The conversion to 3-oxoalanine (also known as C-formylglycine,
CC FGly), of a serine or cysteine residue in prokaryotes and of a cysteine
CC residue in eukaryotes, is critical for catalytic activity.
CC {ECO:0000256|PIRSR:PIRSR036666-50}.
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; UXUI01008136; VDD90598.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4V664; -.
DR STRING; 51028.A0A0N4V664; -.
DR WBParaSite; EVEC_0000573801-mRNA-1; EVEC_0000573801-mRNA-1; EVEC_0000573801.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008449; F:N-acetylglucosamine-6-sulfatase activity; IEA:InterPro.
DR GO; GO:0030203; P:glycosaminoglycan metabolic process; IEA:InterPro.
DR CDD; cd16147; G6S; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012251; GlcNAc_6-SO4ase.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR43108:SF16; EXTRACELLULAR SULFATASE SULF-1 HOMOLOG; 1.
DR PANTHER; PTHR43108; N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF036666; G6S; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 577..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..353
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT MOD_RES 66
FT /note="3-oxoalanine (Cys)"
FT /evidence="ECO:0000256|PIRSR:PIRSR036666-50"
SQ SEQUENCE 602 AA; 70921 MW; 2CC1227BE51C0CF1 CRC64;
MIIPLILLQI AYTIDVCRTK GKNVVLILTD DQDIELGSME FMPKTRNLLQ VRGITFQSGF
VSTPICCPSR SSILTGQYVH NHNVFTNNQN CSGASWREIY EKQTFGVYLQ KKNYVTAYFG
KYLNEYDGSY QPPGWNEWMG LVKNSRFYNY TVVLNGEKIK HGFDYERDYF TDLIANDTIA
FLKKHCKRQP TKPFLVVLSF PAPHGPEDPA PQFSHLFENV ETHRTPSWNY APNPDKQWIL
QHTGRMEPVH VVFTDLLHRR RLQTLQSVDH NIQRLFNELR NVGVLSQTYI IYSSDHGYHL
GQFGLVKGKN MPYEFDIRVP FFIRGPDTPR NITIREPVMN VDIAPTILDV AGIKAPPQMD
GRSLLPLIKA YGARKARSLR KLRWRHTVLI ERGKMTKLKN LRVRLEMQSN HVQENSMLYA
HCKRPEFNGF CDEKQDSEYV LHLDEEKLRW NGTVAELYER SVKVLIDGRL RIRWRSEFLN
YLHQVNYLNR KSELLETKTQ CHVPQMNCFL HGTDHWRTPP LWPQEYGEFC FCQNANNNTY
WCLRTVNETH NFLYCEFLTE FISYYDLITD PYQVSNLFVY FMHSNFFFFP CFLLHFKSKI
SK
//
