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Database: UniProt
Entry: A0A0N4VAM1_ENTVE
LinkDB: A0A0N4VAM1_ENTVE
Original site: A0A0N4VAM1_ENTVE 
ID   A0A0N4VAM1_ENTVE        Unreviewed;       862 AA.
AC   A0A0N4VAM1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   12-APR-2017, entry version 6.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Enterobius vermicularis (Human pinworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Oxyurida;
OC   Oxyuroidea; Oxyuridae; Enterobius.
OX   NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000753401-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000753401-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EVEC_0000753401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; EVEC_0000753401-mRNA-1; EVEC_0000753401-mRNA-1; EVEC_0000753401.
DR   Proteomes; UP000038041; Genome Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038041};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038041};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    427    452       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    472    490       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    568    589       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    595    622       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    634    654       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    690    709       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    777    795       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    801    826       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      100    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   862 AA;  98364 MW;  0202A09EAA7C6E23 CRC64;
     MSLKPNMGSL LRSEEMSLAQ IFFQAESAYT CVAELGELGL AQFRDLNGDV SAYQRKYVNE
     VRRCDEMDRK LRFIEAEIEK DEIEIPDVND YIPFPLPKDM NDLEAKFERL EEELLEINAN
     TNTMRKNYKA VVEMSQVLDH VQKFLDEGQH EQARAQIAEA QQGIAGPLSE GGLGNAITRA
     VASLTGTEKK ESTEMRFIAG VLARNRAVAF ERMLWRWCRG NVFVRTADIP DTYDQLLEEN
     DGKVVFIIFF YGEALEQKSK KICDGFRASI YKCPETSDAR RAMKQEVLLQ TEELKSVLLK
     TMEHRDKVLR ATAQNYKTWT IKVLKIKSIY HTLNLFNLDI TQKCLVAECW IPKTDIPLVL
     DQLNLGAKNA GSNIAPVLNV MTTNEEPPTF HRTNKFTRGF QNIVDSYGIA TYREINPAPW
     TIISFPFIFA IMFGDAGHGI IMFLAALMFV IFEKKLISMK IKDEIFNTFF GGRYVILLMG
     IFSVYTGLVY NDIYSKSINI FGSSWRNPYN KTLLAILDES DTDVELTMPP HPAFDYINGP
     YPFGVDPIWN IATNKLNFLN PLKMKMSVII GIAQMAFGLM LSLFNFIYFR SAIDILFIFI
     PEVLFLSCIF VYLCIQIIIK WLMFWVRPVY IFGWYYPSSH CAPSLLIGLI NMFMMKSREE
     GFVDKNDPRN ELDQCYLQQW YPHQSMVETI FLIIAVISIP VMLLVKPILL KIQAARGKHV
     GGHGHGGGGE GEEFNFGDVL VYQAIHTIEF CLGCISHTAS YLRLWALSLA HAQLSEVLWS
     MVFNIAYTIG GWGGLIAQFI IFWIFAILSV SILILMEGLS AFLHALRLHW VEFQSKFYGG
     LGYQFEPFSF EAIIRVAEGL DN
//
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