ID A0A0N4VEW6_ENTVE Unreviewed; 519 AA.
AC A0A0N4VEW6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 22-FEB-2023, entry version 23.
DE SubName: Full=SAM domain-containing protein {ECO:0000313|WBParaSite:EVEC_0000924001-mRNA-1};
GN ORFNames=EVEC_LOCUS8681 {ECO:0000313|EMBL:VDD93930.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000924001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000924001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD93930.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; UXUI01009554; VDD93930.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4VEW6; -.
DR STRING; 51028.A0A0N4VEW6; -.
DR WBParaSite; EVEC_0000924001-mRNA-1; EVEC_0000924001-mRNA-1; EVEC_0000924001.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09515; SAM_SGMS1-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF25; SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 212..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..104
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 59635 MW; C717AA7614885681 CRC64;
MRLDPYPQLP AADARPQTNG GIHSARDVDY HRKPVKDWDY ADVAEWLSSE GFSAFANLIA
FEHKIDGSML LMLTEKDLRE KPLEMTCLGD IKRLAIAISM LRDSAHPKLH TFPSTSSVQE
PVHSSPKKTI SKTAREHEDM LVCVEVEDGV VPIANADSKI LADTRENANR VLTEIMSKDG
EGEVRRVHLL SREEIIRQVE SPDTKNKSYV KLFIAFCYCS FSLLITAFTM VIVHDRVPDM
KTYPPLPDVV LDNLPFIPWA FEMCELIAVC LSTVWFIILF FHKHRVVIMR RMFSLTGTVF
LLRCVTMIIT SLSVPGAHLE CRAKTYGSLW AKLWHAYHIW SKLGMSIRGV RTCGDYMFSG
HTTAITLLNH LITEYTPDSW HGLHTATWVL NLFGIFFILA GHEHYSIDVF IAFYISSRMF
LYYHAYAYNH YNLTFQDGRM RIWFPLGWFF EAGGHGRVPN EYEFPFSLPD VSWLSRKRNP
SPTVVGSGEK RTRIPSLSLD RKNPSPENNN KPTRRRRKR
//
