ID   A0A0N4VGE4_ENTVE        Unreviewed;       766 AA.
AC   A0A0N4VGE4;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00026121};
DE            EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
GN   ORFNames=EVEC_LOCUS9240 {ECO:0000313|EMBL:VDD94489.1};
OS   Enterobius vermicularis (Human pinworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX   NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000985501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EVEC_0000985501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDD94489.1, ECO:0000313|Proteomes:UP000274131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UXUI01009908; VDD94489.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4VGE4; -.
DR   STRING; 51028.A0A0N4VGE4; -.
DR   WBParaSite; EVEC_0000985501-mRNA-1; EVEC_0000985501-mRNA-1; EVEC_0000985501.
DR   Proteomes; UP000038041; Unplaced.
DR   Proteomes; UP000274131; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:UniProt.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43272:SF106; FATTY ACID COA SYNTHETASE FAMILY; 1.
DR   PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274131};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        61..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          160..581
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   766 AA;  86390 MW;  4DF32FAF27BD0BC1 CRC64;
     MCIKGDEKTE VQEKPQKTVD KLVKVSFKFC SNVYLLFFTL ITFRTLENLS INIKIQGRSP
     LWIRIIIFII QVWFFIYDYI NYIPFELFSP PMEKLRKSAR VKARSLKGPG GPWRHVTGIR
     NETYPGKNTI DKLFAHVTSL YHNRPMLGTR EILSIHEETQ PDGRIFEKWG MGVYSWQTYG
     EVHRRVGYLA AGLRELADKD AKLLIFAETR ADWLITAFAC FRANIVVVTA YATLGEEAII
     GAINETEATM VVTSAEILPK FTKAVDRCPA VKTMIYFPVR HKSTRLCDLT IFESRLQHVL
     SFEKLENMCA FPLETSTATP DDLALIMYTS GTTGVPKGVM MTNQNIVAAL AGIGPGVEVV
     TEKDTMISFL PLAHIFELLT EMICLVHGTR LGYSSTLTFH DRGTKVLPGT RGDCYALNPT
     LMAGVPVIWD RIFKAVSEEI SQTPRFIQEL FKLNYERKRA RFESGYSSPF LDRIVFKKIR
     KLLGGKIKAV ISGGATLNAE THRFLNICIC PTVLQGYGLT EICAAGAISD QYDLSTGTVG
     PPLRCSQFIL EKWEEGGYSP ENNPPQGEIL IGGNSVSIGY WKQPEKTAES FVVIDGVRYF
     RTGDIGQMRD DGSLMIIDRK KDLVKLRDGE YIALAKVEVA LSTSSLIDMI CVYGDSLELY
     LVALIVPNKQ HLEKLANEIG ESTGAWSELC SNKQVIDEFK ARLDQHALKN RLMKKEVPRK
     IHLCDEIWTP ESGLLTEAMK IKRIPVLKKY CKVIDQLYER SPGMQR
//