ID A0A0N4W2X9_HAEPC Unreviewed; 701 AA.
AC A0A0N4W2X9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Arf-GAP domain-containing protein {ECO:0000313|WBParaSite:HPLM_0000411901-mRNA-1};
GN ORFNames=HPLM_LOCUS4111 {ECO:0000313|EMBL:VDO22439.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000411901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0000411901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO22439.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO22439.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UZAF01016175; VDO22439.1; -; Genomic_DNA.
DR STRING; 6290.A0A0N4W2X9; -.
DR WBParaSite; HPLM_0000411901-mRNA-1; HPLM_0000411901-mRNA-1; HPLM_0000411901.
DR OMA; RENEVNW; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd08833; ArfGap_GIT; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF3; ARF GTPASE-ACTIVATING PROTEIN GIT; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 24..154
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 195..227
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 497..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 78074 MW; 0D60D5D188AA9749 CRC64;
MTSSIGPSIG SDVLSLCSSM DSSAVVLSPI AHASSVEIIQ CADCSADDPQ WASINRGVLI
CNDCCSVHRN LGRQYSQVRS LNRGMWDTPQ LELVKLLHKT GSNRVWEHAM LDPASSSKFK
RKPLPHDPVL PTKEAFIKAK YVDHAFIRRP SKDDEPWSLD DVNKQLWSCV RTAHVDTTLR
LLAMGADVNY VDTEKGNSPL HVAAKEGQAM QVELLYIYGA DPLLSNAADL TPAQLARQDG
FVDLANRLDE LSFDLTNRLS LFLCGRKPDH QHQQHFLIPE LTAKNTVETL RSVRLKIQAL
PDCAFEKLLQ DVYDEVDRRE TQAAWMAMNQ GKITSGNEQC VAVFLPLNTS FSATRNQLRQ
KLAKYDVREF ATLIIDVLKE AKRRYFGLPP ELSQDNLDTS TNLHNISRRS SGNKTRSTSS
IDAAIDGRVS IDDVLELKER MTENETKLTS ICHTNTQIMK QIVRLSEQAA LLRRLPSPAT
VPHVTANHIV ERAHSVGVDR SDRIGRPPIE AESRIAKRHG SMSGATPGYS RMVPSGRKSA
ENHRDRDEPR DSSREKLRSR ENRDRNLDST DYASITPAPQ VVASKVQEAF SEPMFPDNLI
RETENLTVAI RSLLTDAQHK QLHGRSSDHA HKIASLINHI ICLIPREQRI GKTEQAVTGL
MDATMVLSAK CNAPILDAED ACHAAYSVAQ SAKMLLMAVH H
//
