ID   A0A0N4WCZ2_HAEPC        Unreviewed;       936 AA.
AC   A0A0N4WCZ2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=HPLM_LOCUS8415 {ECO:0000313|EMBL:VDO34801.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000842301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0000842301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO34801.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO34801.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; UZAF01016857; VDO34801.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4WCZ2; -.
DR   STRING; 6290.A0A0N4WCZ2; -.
DR   WBParaSite; HPLM_0000842301-mRNA-1; HPLM_0000842301-mRNA-1; HPLM_0000842301.
DR   OMA; FYLWFFL; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        428..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        473..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        565..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        605..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        645..664
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        685..704
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        724..745
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        864..888
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          60..137
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   936 AA;  107252 MW;  9B588DF958C3DAE9 CRC64;
     MSSSEPEPDQ PGIYRSEQMT LAQLFLQSEA AYQCVAELGE LGLVQFRDLN PDTSAFQRKY
     VNEVRRCDEM ERKLRYLERE IKKDQIPMLD TGENPDAPQP REMIDLEATF EKLENELREV
     NRNEETLKKN FSELTELKHI LRKTQTFFEE VEHDRRHIGE ASRRRTLSED QEPLIVTAEE
     EASLGLGLSM TMLRLGFVAG VIRRERLPAF ERLLWRACRG NVFLRTSEID DVLNDTVTGE
     PVNKTVFIIF FQGDQLKTKV KKICEGFRAT LYPCPDTPQE RREMSIGVMT RIEDLKTVLG
     QTQDHRHRVL VAASKNVRMW LTKVRKIKSI YHTLNLFNID VTHKCLIAEC WCPVSELERI
     KMALKRGTEE SGSQVPSILN RMETTEAPPT YHKSNKFTRG FQNIVDSYGV ATYREINPAP
     YTMISFPFLF AIMFGDLGHG LIMLAAALFF ILKEKQLEAA RIKDEIFQTF FGGRYVIFLM
     GAFSIYTGFL YNDIYAKSVN VFGSGWTNCY DLTEIERLKY GAERNLMLIP EKAYDTAGGP
     YPIGVDPIWN LAESNKLNFL NSMKMKISVI VGIAQMTFGV LLSYQNYKYF KSDLDIKFMF
     IPQMIFLASI FMYLCLEIVV KWIFFTAGVN SIFGYKYPGS NCAPSLLIGL INMFMFKALP
     SGFVEEDGHQ KFQCHLNFWY PGQGFFQTLF VLVAIACVPI MLFAKPYMLW KADKERRESG
     HRQLGIVERV LLVLAVVQVP LMLFAKPLIL RYRSRVTNAH YYTLRDESVR ADMNGDDAEV
     VHAEPKTTST VGSGGGDHGH GGSGPFEFGE VMVYQAIHTI EFVLGCVSHT ASYLRLWALS
     LAHAQLSEVL WSMVFRHSFR LDGYYGAVAT YVLFFIFGSL SIFILVLMEG LSAFLHALRL
     HWVEFQSKFY GGLGHAFTPF SFEKILEEER EAEETL
//