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Database: UniProt
Entry: A0A0N4WCZ2_HAEPC
LinkDB: A0A0N4WCZ2_HAEPC
Original site: A0A0N4WCZ2_HAEPC 
ID   A0A0N4WCZ2_HAEPC        Unreviewed;       936 AA.
AC   A0A0N4WCZ2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   20-DEC-2017, entry version 11.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000842301-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000842301-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:HPLM_0000842301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; HPLM_0000842301-mRNA-1; HPLM_0000842301-mRNA-1; HPLM_0000842301.
DR   Proteomes; UP000038042; Genome Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038042};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038042};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    428    452       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    473    491       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    565    584       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    605    625       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    645    664       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    685    704       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    724    745       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    864    888       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       60     80       {ECO:0000256|SAM:Coils}.
FT   COILED      103    137       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   936 AA;  107252 MW;  9B588DF958C3DAE9 CRC64;
     MSSSEPEPDQ PGIYRSEQMT LAQLFLQSEA AYQCVAELGE LGLVQFRDLN PDTSAFQRKY
     VNEVRRCDEM ERKLRYLERE IKKDQIPMLD TGENPDAPQP REMIDLEATF EKLENELREV
     NRNEETLKKN FSELTELKHI LRKTQTFFEE VEHDRRHIGE ASRRRTLSED QEPLIVTAEE
     EASLGLGLSM TMLRLGFVAG VIRRERLPAF ERLLWRACRG NVFLRTSEID DVLNDTVTGE
     PVNKTVFIIF FQGDQLKTKV KKICEGFRAT LYPCPDTPQE RREMSIGVMT RIEDLKTVLG
     QTQDHRHRVL VAASKNVRMW LTKVRKIKSI YHTLNLFNID VTHKCLIAEC WCPVSELERI
     KMALKRGTEE SGSQVPSILN RMETTEAPPT YHKSNKFTRG FQNIVDSYGV ATYREINPAP
     YTMISFPFLF AIMFGDLGHG LIMLAAALFF ILKEKQLEAA RIKDEIFQTF FGGRYVIFLM
     GAFSIYTGFL YNDIYAKSVN VFGSGWTNCY DLTEIERLKY GAERNLMLIP EKAYDTAGGP
     YPIGVDPIWN LAESNKLNFL NSMKMKISVI VGIAQMTFGV LLSYQNYKYF KSDLDIKFMF
     IPQMIFLASI FMYLCLEIVV KWIFFTAGVN SIFGYKYPGS NCAPSLLIGL INMFMFKALP
     SGFVEEDGHQ KFQCHLNFWY PGQGFFQTLF VLVAIACVPI MLFAKPYMLW KADKERRESG
     HRQLGIVERV LLVLAVVQVP LMLFAKPLIL RYRSRVTNAH YYTLRDESVR ADMNGDDAEV
     VHAEPKTTST VGSGGGDHGH GGSGPFEFGE VMVYQAIHTI EFVLGCVSHT ASYLRLWALS
     LAHAQLSEVL WSMVFRHSFR LDGYYGAVAT YVLFFIFGSL SIFILVLMEG LSAFLHALRL
     HWVEFQSKFY GGLGHAFTPF SFEKILEEER EAEETL
//
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