ID A0A0N4WDE0_HAEPC Unreviewed; 721 AA.
AC A0A0N4WDE0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN ORFNames=HPLM_LOCUS8580 {ECO:0000313|EMBL:VDO35279.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000858801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0000858801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO35279.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO35279.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR EMBL; UZAF01016890; VDO35279.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4WDE0; -.
DR STRING; 6290.A0A0N4WDE0; -.
DR WBParaSite; HPLM_0000858801-mRNA-1; HPLM_0000858801-mRNA-1; HPLM_0000858801.
DR OMA; WIMIRVI; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd17336; MFS_SLCO_OATP; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF151; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 144..161
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 201..226
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 238..262
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 291..317
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 452..475
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 608..634
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 646..669
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 528..586
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 721 AA; 80311 MW; 9CE3070B5616F6FA CRC64;
FLACSVTKHQ VDLKDESHSR QASQGVPYRN VEKPRRIFSH ISLQQNRFDS SVLVQESQCG
LGKWRPSWLS FLGSRRWMIT LLCWYCAVQG IVVNGLVPSA ISSIERRFKL STSTMGRIVQ
FYDFGYVLFC IPVSYFGGRH SKPAVLGAGL ALICIGSLLF STPHMLADSY SANQDHKSLG
SFHFFQLSVP LKNKIRWTFR FVFLFCLAHF LHGIGATPLF TIGVSYIDEN VGKALSSLFV
GIFYSFAVFG PAAGFLTAGT FLTYHTDFWH LPAEQISRVS GDETDPSWVG AWWIGFVLAS
FIAMLAVVPI MCLPKVLPES LKWHRNRLVE TSQAGRRRTP ECCGLAGTNK TAALYRDAPL
PGEFVDLTFL EESSLLYTSI TTRGRGPLWY KLWLDVRHIP IAIYRILTNA PFMLITLAMA
IDSLVVTGAS SFMSKYLERQ FNVPPSSFNM QLLFKFIGCI MVPMAGIGCM ISGFIVQYFR
LNCVTTLKLA VGLLFVSLVL TPMYLIYCPH DPLVDGHISM GNYSDVEPSL RSPCNSHCLC
SEAEFRPVCA EFVDGRQLSY YSPCFAGCSE PYTPMQKVYT NCSCVVETPR LRVKQVKKGL
CESKCKGLLG FLIMFAPLSL CTFAVGVPII SVILRTVDYN ERSFALGIQG ILVRVVGTIP
APVLFGWMFD VSCIRYQSEP CGDSESGSCL LYSNKLLADL FLTFSIIGQV RVLHFSSVGL
N
//
