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Database: UniProt
Entry: A0A0N4WGH5_HAEPC
LinkDB: A0A0N4WGH5_HAEPC
Original site: A0A0N4WGH5_HAEPC 
ID   A0A0N4WGH5_HAEPC        Unreviewed;       949 AA.
AC   A0A0N4WGH5;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   07-JUN-2017, entry version 8.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000991101-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000991101-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:HPLM_0000991101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; HPLM_0000991101-mRNA-1; HPLM_0000991101-mRNA-1; HPLM_0000991101.
DR   Proteomes; UP000038042; Genome Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 3.
DR   PIRSF; PIRSF001293; ATP6V0A1; 3.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038042};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038042};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    446    464       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    546    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    678    701       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    826    845       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    865    884       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    890    914       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       96    123       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   949 AA;  108735 MW;  5B7455F76F064BC3 CRC64;
     MGAFVRSEEM RFCQLIVEKE AAFNCVAELG KQPYVQFKDL NPDVNPFQRT FVRHIRRYDE
     MERKLRFLES QITKDEIPIA GRLVQGDYTV MPTAELNQLE TTLTDLERDV QNMNESDAQL
     KKNYMELKEW DAVLEKTDEF FHGGLDDQAA EELDIQEEEY GKGEKAPISY VVGVIRRERL
     LVFERVLWRA SHHTAYLRSS NIEEDLEDEN NLKVHKAVFI VFYKGDRLRS IVEKVCDGFK
     AKLMKNCPKT FKDRQSARID VKARLQDLKT VLGQTREHRY RVLQAAANNH NNWLRQVRMQ
     KTVYHHLNLF TFDGIGKFFV AECWVPLVHM DEVKAALDRG AQISGSTVQP VLNVLETHDE
     PPTYNRTNKF TEVFQGIVDS YGIATYQELN PAPYTIISFP FIFACMFGDL GHGLLMFLCG
     LYFVLREKNL ISRNIKDEIF GMFFGGRYII LLMGLFSIHA GIIYNDAFAK SFNIFGSTWL
     NPYRQVQQEL SGWINESGAA NKELLIEMDP GYSYQHADGP YPYGVDPIWN VAENKLNFLN
     SMKMKLSVIA GIAQMTFGVV LSFYNYRFFK SKIDIYTVFI PQMLFMTCIF IYLCLQIVIK
     WIFFWVKPEM IFGQLYPGSH CAPSLLIGLI SMFMFKDRPA GFVQMDKIVG EKNGQVQYVE
     QDQCYLTQWY PGQSGVEAVL VIIAVLCVPV MLFGKPIYFI MEQRKKKKAM GSNISVRANV
     VSDDSEIIIN GNHKKDEPEA ASAHGHDEAF GDVMVHQAIH TIEYVLGCVS HTADDSEIII
     NGNHKKDEPE AASAHGHDEA FGDVMVHQAI HTIEYVLGCV SHTASYLRLW ALSLAHARLL
     FFFFFDIHVI RGGSIERIQR ELSEVLWHMV LSNAFILSGI AGYIAIYVIF FFFAVLTFSI
     LVLMEGLSAF LHALRLHWVE FQSKFYQGLG YAFVPYSFKT ALEAAEAGN
//
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