ID   A0A0N4WGT6_HAEPC        Unreviewed;       725 AA.
AC   A0A0N4WGT6;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Hist_deacetyl domain-containing protein {ECO:0000313|WBParaSite:HPLM_0001005001-mRNA-1};
GN   ORFNames=HPLM_LOCUS10042 {ECO:0000313|EMBL:VDO39050.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001005001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001005001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO39050.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO39050.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC         [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC         COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:61930; EC=3.5.1.98;
CC         Evidence={ECO:0000256|ARBA:ARBA00001028};
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DR   EMBL; UZAF01017201; VDO39050.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4WGT6; -.
DR   STRING; 6290.A0A0N4WGT6; -.
DR   WBParaSite; HPLM_0001005001-mRNA-1; HPLM_0001005001-mRNA-1; HPLM_0001005001.
DR   OMA; QKVIAIH; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF15; HISTONE DEACETYLASE; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014}.
FT   DOMAIN          343..656
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          124..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   725 AA;  78325 MW;  12E0BE162A7017B9 CRC64;
     MCFPIFSFEC FDNHCFRFFS EHRNASTNST STTISQHTKD RLKNMIAQRN REGSQTNLAG
     TASLIPLYGP SLQVNVSSPH FEPYRVPASL HSVQAVSCQP SGEYQLRKVN SEPNLKMRIR
     AKLLSKGSSP VQNQSSFSFT HPQLKRSDSE TSSNGGTTGG ANLAMDALLS NAAATAFPPH
     LIMPSPSLPN LAAPTLAQPP QLPIGNHSNM ASLMAAAQLT PFLSLPSLLK TQLGLGGGLL
     EDDITDRSKL APGVAALGAL SQQVPVGGYP SLLKQQLREL VLRRKSLVRE EPEDDDSLVT
     QPVLGQMPTT LGLGELSSGK ATGLAYDSSM ARHECVCGES SSHVEHGGRV QSIWARLLER
     GLVQRCERTA AKKASLEQLR MVHSPTYVTF FAVSPTACLK MEASQLPLKS FVQLPCGGIG
     IDSDTYFNDA TTQTAARVAA GSLIELASQV AENRLRNGFA CIRPPGHHSE RDQAMGFCFF
     NNVAITARYL QQKYPRQCSR IAIIDWDVHH GNGTQLCFEE DPSVLYLSLH RHDNGNFFPG
     TGAVTEVGRG AGKGYSVNVP FSGGVMRDAD YLAAWRVVVH PILEQFQPNF ILVSAGFDAC
     CGHPNALGGY KISAEMFGFM TRQLMGFAGG RVVLALEGGY DLASISDAAE QCVKVLCGDD
     DKAGLLNSEA LEGIPCLSAQ ETIQKVIAIH KGYWPNLTAE QGLTTSELHW QTVGRQFQNL
     TMGTV
//