ID   A0A0N4WJX1_HAEPC        Unreviewed;       694 AA.
AC   A0A0N4WJX1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Metal transporter CNNM4 {ECO:0000313|WBParaSite:HPLM_0001134001-mRNA-1};
GN   ORFNames=HPLM_LOCUS11332 {ECO:0000313|EMBL:VDO42613.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001134001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001134001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO42613.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO42613.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ACDP family.
CC       {ECO:0000256|ARBA:ARBA00010484}.
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DR   EMBL; UZAF01017537; VDO42613.1; -; Genomic_DNA.
DR   STRING; 6290.A0A0N4WJX1; -.
DR   WBParaSite; HPLM_0001134001-mRNA-1; HPLM_0001134001-mRNA-1; HPLM_0001134001.
DR   OMA; YGNHLDK; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:UniProt.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   GO; GO:1905941; P:positive regulation of gonad development; IEA:UniProt.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 1.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        135..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          129..309
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          395..467
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   694 AA;  77357 MW;  8B37D27B3B036F89 CRC64;
     MRLPSIFGMR VELPADDPFG YDKHGVCIVT PDEQFKVVIY GNHLDKIAQL IFTPTNSCSD
     GKHVVDATND FIVHFTHKAT FHLMLPMLPE SIHAYKMCVK PKGALPGMEL SPLDDISTWI
     TTEKPPKEYF LPLPVQVTVI AFLLCLSALF SGLTLGLMSL TPQELELVMK AGSPSEQKYA
     AVILPIRRKG NLLLCSLLLG NVIVNAAISI LFGELTTGLL ALFISSLGIV IFGEIVPQSI
     CVKKGLAVGA HTILITQVFI FITYPVAWPV SKLLDCLLGD EYQAYDRKRL MELIRMSIKN
     DNGQLSNELK IAVGAMEIAD KVAEDVMTKL ADVFMIPDTT VLNTKTVAEI VRMGYTRIPI
     YSEGDKNNVT DILFVKDLAL LDPDDNFTVK TVCGYHRHPV KFVFNDTPLS VLLEAFKKTG
     YFKGEGHLAM VKKLVGAEDH DPSYELVGVV TLEDIVEEIL QAEINDEFDV VSDNVNKIKR
     KNLQAEINDE FDVVSDNVNK IKRKNLQQRD MSKMFDKEAP QIQISLQIQM VALQWLVANE
     EAFSPTYVDK NVLERLIRNS ARRVDISALM AMSHSAVNVP KVAKLYTKDE MSDRFVLILE
     GRVQVTIGQS GMMFEAGPWH SFGSEILKKL VQGAATLSRS TSIVDTTDLS CRRPDLMFKP
     DYSVVVKEDC TYLDVSVAAY INAYKSSLMQ REKG
//