ID   A0A0N4WRZ0_HAEPC        Unreviewed;       635 AA.
AC   A0A0N4WRZ0;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   ORFNames=HPLM_LOCUS14266 {ECO:0000313|EMBL:VDO52297.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001427401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001427401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO52297.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO52297.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC       {ECO:0000256|ARBA:ARBA00005446}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UZAF01018504; VDO52297.1; -; Genomic_DNA.
DR   STRING; 6290.A0A0N4WRZ0; -.
DR   WBParaSite; HPLM_0001427401-mRNA-1; HPLM_0001427401-mRNA-1; HPLM_0001427401.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd18794; SF2_C_RecQ; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR032284; RecQ_Zn-bd.
DR   InterPro; IPR018982; RQC_domain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR   PANTHER; PTHR13710:SF120; WERNER SYNDROME ATP-DEPENDENT HELICASE; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   Pfam; PF16124; RecQ_Zn_bind; 1.
DR   Pfam; PF09382; RQC; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014}.
FT   DOMAIN          140..295
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          426..506
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
SQ   SEQUENCE   635 AA;  72246 MW;  4A38090068B73940 CRC64;
     SLRYNFQEYV HLDDISKPTP TGNRSQSFRD STFLSATPSQ KALQTLKVIC RSSLVLRGNQ
     RNDGSSRKPS GIFWNFYRAS MKAYFLFQHY FGHSSFRPKQ WDIVRNALEG KDQLVLMSTG
     YGKSVCYQLP GLMSSFLTLV VSPLISLMND QGRHFGGATI IYCQTRAMVE SVHEYLRGRG
     VKCAMYHAGL SDKARNDAHH GFIQDKYTTI VATVAFGMGI DKSDVRKVIH CGSPKDIESY
     YQEIGRAGRD GDPAHCYVLW TQKDIVMNRA RINNSMKEPY LSHAYEMIRA MEEFLSSMRC
     RRYLLLSHFD TSTPAPLNPQ TDCCDNLSYL NEFCRGRGSN QKIFGIGKGR SDKWWKALGA
     QLRIHGWLVE IKKGDMVYGA CVKLSEKAKK WYLANNEVRR ILGATRLFLH PYNLFVTVPQ
     LIQLTKHQVE ELRRVLDNVR MELAKEYDCG PFQIASNKVL DQLANIRPNS VAALESISDL
     PVERRQRFGQ RFTDCIKEFA AAHNLDTNVS TSSTVSLYIA KHVFFLGSDI SKMRCISEST
     TWGNLCSAVE LGLPLHLDKL VRKLISGNQT NFFLNFVIVS VSSDVYRLKQ LMEALPPDFI
     DYNRLKIIRA ILLWEYEANT TETSSSGTMD ILIQA
//