ID   A0A0N4XGF3_NIPBR        Unreviewed;       321 AA.
AC   A0A0N4XGF3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Aldo_ket_red domain-containing protein {ECO:0000313|WBParaSite:NBR_0000160501-mRNA-1};
GN   ORFNames=NBR_LOCUS1606 {ECO:0000313|EMBL:VDL65146.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000160501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0000160501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL65146.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYSL01001363; VDL65146.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4XGF3; -.
DR   STRING; 27835.A0A0N4XGF3; -.
DR   WBParaSite; NBR_0000160501-mRNA-1; NBR_0000160501-mRNA-1; NBR_0000160501.
DR   OMA; CPCPFKH; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF291; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162}.
FT   DOMAIN          34..284
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        39
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         101
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            68
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   321 AA;  36471 MW;  EA1015DE0EC475F9 CRC64;
     MIVRHVAEFM IGDVEFAKDE QELTVSLRTA LDNDTAFLYQ NEAIIGKVLN ENLSSGKLKR
     EELFITTKLP FTGHDPEDVE KCVNKQLEAL QLDYIDLYLM HSPCPYERNP DSFVPKVIDG
     AFVPVMIEHI DTWRAMEKLH AAGKLKALGV SNFNAEQVEL LYHQAHVKPV NIQVECHLYL
     PQFELQELCK KLNISFTAYA PLGSPGRKVS RPDGVWPEGD PMTDSLVKQI AAKHDKTPAQ
     ILLRHLTQRG ISAIPKSINP DRIVENISIF NFKLTPEEVE QLNSVPTRIR LFMFDFAVGH
     PYFPHEDIEQ AIAPKTALRL H
//