ID A0A0N4XIM1_NIPBR Unreviewed; 556 AA.
AC A0A0N4XIM1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=NBR_LOCUS2374 {ECO:0000313|EMBL:VDL65963.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000237301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000237301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL65963.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; UYSL01002655; VDL65963.1; -; Genomic_DNA.
DR STRING; 27835.A0A0N4XIM1; -.
DR WBParaSite; NBR_0000237301-mRNA-1; NBR_0000237301-mRNA-1; NBR_0000237301.
DR OMA; XPETLMR; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF109; ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162}.
FT DOMAIN 1..74
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 99..278
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 556 AA; 63122 MW; 52E087B855F6406E CRC64;
MLLREAMNCP LLDGYGVIIL DEAHERTLAT DILMGLIKEI VKQRADIKIV IMSATLDSGK
FQNYFENCPL MSVPGRTFPV EIFFTPEPEK DYLEAAIRTV IQIHVCEEVE GDILLFLTGQ
EEIEEACKRI KREVDNLGPS VGTLNCIPLY STLPPNQQQR IFEPPPPSKP GAIGRKCVVS
TNIAETSLTI DGVVFVIDPG FSKQKVYNPR IRVESLLVCP ISKASAMQRA GRAGRTKPGK
CFRLYTEKAY QEEMQEQTYP EILRSNLGSV VLQLKKLGIE DLVHFDFMDP PAPETLMRAL
ELLNYLAAIN DDGELTELGS LMAEFPLDPQ LAKMLITSTE LNCSNEMLSI TAMLSVPQCF
VRPNEMKKEA DEAKARFAHV DGDHLTLLNV YHAFKQNNED VQWCYDNFIN YRTLKTADTV
RTQLGKIMDK FNLRRVSTDF KSKDYYINIR KALVAGFFMQ VAHLQRSGHY VTVKDNQLVN
LHPSTVLDHK PEWALYNEFV LTTKNFIRTV TDVRPEWLLT IAPQYFDLSN FPDGDTKRKL
QYVANSLRAL QSSKGY
//
