ID   A0A0N4XZ05_NIPBR        Unreviewed;       361 AA.
AC   A0A0N4XZ05;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Napsin-A (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:NBR_0000836201-mRNA-1};
GN   ORFNames=NBR_LOCUS8363 {ECO:0000313|EMBL:VDL71952.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000836201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0000836201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL71952.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UYSL01019996; VDL71952.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4XZ05; -.
DR   STRING; 27835.A0A0N4XZ05; -.
DR   WBParaSite; NBR_0000836201-mRNA-1; NBR_0000836201-mRNA-1; NBR_0000836201.
DR   OMA; CATIRTQ; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966:SF8; ASPARTIC PROTEASE 1-RELATED; 1.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   Pfam; PF00026; Asp; 2.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..361
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5033231588"
FT   DOMAIN          62..356
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   DISULFID        280..316
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   361 AA;  39746 MW;  8D94997D193794DF CRC64;
     MWALKVVVIV IIGGDTSSPK LMDSPPEVFK TIGAEQYNFR DRGRSKRFVT SHGLVDYYDV
     HYLGIIGIGT PRQNFLMMMD TGSSGIWVID QSCNTATCNG NPRNGRSRSK YNPAWSYTFR
     FIARNFSTGY ASGGVSGYEA EDSVHVGGVT VTGQRIGVAT HVDNGWATSP IDGIFGLGWP
     TAGAIYPVSR GQSAGVITYG AVDNINCRPY WVYVPMTRPS MWEVPLQGFR MGSYSITGSY
     KVLVDSGSSR MGVPNSVLNA IVQQTSARWN NQHNGHTVSC ATIRTQPIIH YSIEGIDYTL
     PSDQYVVDTN MGNNECLLAF YGTTGLGLYT EWILGMPWFR AYCNLFDFGN RRVGFSVAIP
     R
//