ID A0A0N4XZW9_NIPBR Unreviewed; 4207 AA.
AC A0A0N4XZW9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Dynein heavy chain, cytoplasmic (inferred by orthology to a C. elegans protein) {ECO:0000313|WBParaSite:NBR_0000877101-mRNA-1};
GN ORFNames=NBR_LOCUS8772 {ECO:0000313|EMBL:VDL72361.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000877101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000877101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL72361.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; UYSL01020049; VDL72361.1; -; Genomic_DNA.
DR STRING; 27835.A0A0N4XZW9; -.
DR WBParaSite; NBR_0000877101-mRNA-1; NBR_0000877101-mRNA-1; NBR_0000877101.
DR OMA; NERQMTR; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162}.
FT DOMAIN 1771..1906
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2066..2199
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2393..2543
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2685..2851
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 494..521
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2957..3033
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3165..3220
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4207 AA; 479160 MW; FFFC847368B4B4C7 CRC64;
MVIFTVRNDV LYRTDKSTSI VFVKRGGVVE ADKSIADQLR VIVLNEGNPY ETLFSLIGKA
VTPYFKSFIK ESGRGERDGD KLAPTVEKNL NEAEVALLHL QQNIDIPEIN LVINPHIQAA
IQKASKEGRK AKVTDLGDLV EDAQFLNSLQ SGVNRWIKEI RKVTKLERDP GSGSSLQEMT
FWLNLERALQ KILQKRESEE VTLTLEALKC GKRFHATVSF DTDTGLKQTL ALVNDYNSLM
KDFPLNELVS ATDLDSIKVA LGNVFGHMKK IRATKYPVQR ALRFIEAISR DMNGQILKVL
GTRRLMHISI VEFDQLMMQC IQLFTKWDDE YDKFITLLRD ISKKKRDEPV KLMWKVMPLH
KKLEGRLVQI KAFRKQHEQL RVVIARVLRP AGTPSTETQP DTQSHSGDIT PVDQVNLAYE
FVKEVDCLDV SLEGTAAWDA AQRRYEEQIA RVETAITSRL RDQLGSARNA NEMFSIFSRF
NALFCRPQIL GAVREYQTQL IQRVKEDIER LQAKFTKHYA EKRGEILTPT FDIPPVSANI
IWIRQIERQL SLYMQRVASV LGTGWENHVE ARQLKTEADN FRKVLDTQPL FENWVEQVLA
KGLSMPGRVF VIDRRSKDGK PHLHLKVNFS PESIVLHKEV RNLKNMGFRI PLKVVNAAHQ
ANQIYPFAIS LLESTRTYES INERLSAKTG IDTLIASYKK DIQSQIADGY QLNWESYKID
PYVTKLADTV NNYQERVEEL ILIADNIEVD LAALDTCQYN AATIGAQLAS IQKSVDQLAL
GNYSNLTQWV EKLDSKIEAK LAARVEEAIR LWTLVYSASE EVDEYKESNV ALPPVHPVLI
EIRLTAQTIY ISPSIEQARA KLLEQLVEWH AVVTSQPRIS STRFQLAMNR DLNVATYKNI
LSRLPNGLGV LEKAYTTVDR ILREVDEYVN EWLRYQALWD LQAEMLYERL GTDLSKWMKT
LVEIRKSRST FDTQDTKKEI FPVIVDYAKV QLKVTLKYDY WHKEVLQKFG TAVGNEMHQF
FGNISKWREE LESQGVDSGT TTDAVALITY VQTLKKQTKV GQETVDQFRA AQRLLSQQRY
QFPAQWLYAE NVEGEWSALT EILLRKDSSI QSQVNNLQTK IREENELVEK RTQETLSEWE
RAKPVEGAQR PSEALMALNT FEQKIAKLSE DREKMRRARH ALDMADPTGV PVDADKLAVA
AEELADLKGV WQALTPIYTS IDEMKEKTWL SVQPRKLRQS LDELMNQLKH LPVKYKSYKS
YEYAKQMMHN YSKMNMLVME LKSEALKERH WRQMMKELRV NWNLSDLTLG QVWDADLQRH
EHAIKQILLV AQGELALEEF LKQMKDFWQS YDVELVNYQN KTRLIKGWDE LFNKLKEHQN
SLAAMKLSPY YKQFEENALS WEEKLNRISA MFDVWIDVQR RWVYLEGLFS GSADIATLLP
IESARFSSIS TEFLALMKKV TQSPRILDVV GMQGAQRLLD RLADMLSKIQ KALGEYLERE
RASFPRFYFV GDEDLLEIMG NSKDIARLQK HLKKMFAGVT AIDVGEEDRI ITALNSREGE
KVDLVQPVHT KDVRINDWLK ALESEMKHTL ARLLGQSLVH FAKMDIDNVT PEEYMEWLDK
YPAQVIGLTA EIWWSNQMEI ALSDGKNVQS VEQAVSSTLA LLADSVLKDQ PPIRRKKIEA
LITEFVHKRD ACRRLNAADV RSQSDFGWLQ CMRFYFDSKQ PDATRCCIVK IANAQFYYGF
EYLGIQERLV RTPLTDRCYL TMTQALHSRL GGSPFGPAGT GKTESVKALG HQLGRFVLVF
NCDETFDFQA MGRILVGLCQ VGAWGCFDEF NRLEERMLSA VSQQIQTIQE AVRAGGEMTV
DLVGKRLNVN SNIGIFITMN PGYSGRSNLP DNLKQLFRSL AMTQPDRQLI AQVMLFSQGF
RTAEVLAKKI VPLFILCKEQ LSAQCHYDFG LRALKYVLVS AGNVKRDKLA KMGAAALEDV
AEQQMLIQSV CETLVPKLVN EDIALLFSLL TDVFPSIHYT PNQMVELRQH IAQVCDELML
CHADVTGELG AAWIEKVLQL YQITNLNHGL MLVGPSGSGK TSAWKVLLKA LERYEKVEGV
AHVIDAKAMS KDALYGVLDP NTREWTDGLF TSVIRKIIDN VRGESEKRQW IIFDGDVDPE
WVENLNSVLD DNKLLTLPNG ERLAIPPNVR IIFEVADLKY ATLATVSRCG MVWFSDEVVT
TEMMFEHYLS RLRNVSIESE ATIPEDAAPT RSITIQRQCA ATLQSHFSPV LFHGIDLVLI
DLYWFCLQLD QVETFVTRTM LTNVIWAFSG DGKWKCRQQM SDFIRNSTTL TLPPNQQAPL
IDYEVQPSGE WQPWLNRVPV MEIEAHRVAA ADLVVPTIDT VRHEMLLSAW LSEHKPLVLC
GPPGSGKTMT LLAALRSQQD MDVVNVNFSS STTPELLMKT FDHYCEYRRT PNGIVLAPVQ
LSRWLVIFCD EINLPAPDKY GTQRVISFLR QLVELNGFYR ASDHSWVSLE RIQFVGACNP
PTDPGRHPLT LRFLRHEHFT QDDQPHYVYS PRELTRWVRG ISEAIAPLDG ISPDQLVRLW
AHEALRLFQD RLVTDVEREW TDELVNTTAE KYFGGACNTK EALRRPLLYS CWLSKHYVPV
TRDELKDYVS ARLKGFYEEE LDVQLVLFDQ MLDHVLRIDR IYRQPQGHLL LIGTAGAGKT
TLSRFVAWLN GLSVFQLKVH SKYTAADFDE DMRTVLRRAG CRNEKMCFIM DESNMLDTGF
LERLNTLLAN GEVPGLFEGD EHTTLMTQIK EGAQRQGLML DSHDELYKWF TLQVMRNLHV
VFTMNPSGSG LRERASTSPA LFNRCVLNWF GDWADTALYQ VGSELTTTLD MDRTDYEPPF
SLPTVCDLVP TPPTYRHAVI NTLVHVHKTV QKLNEQEQKR GHRVMVVTPR HFLDLIKHFM
NLFHEKRRDL EEEKVHLNIG LNKIRETEEQ VKELQKSLTL KSRELEEKKT AANLKLKEML
ADQQKAEDEK RLSEQLQKEL SAQLTQIAAK KTEVQKDLSQ VEPAVEEAQQ AVKGIRKTQL
VEVRSMASPP VMVKLALEAI CILLGENVGT DWKAIRGVMV KDDFMPRILA FDTDSITTDI
LKQMDKYVNN PDWDFDKVNR ASQACGPMVK WAKAQLLYSG MLHKVEPLRN ELKRLESDAK
KKTTEGNEVK ARIAQLEQSI AAYKEEYAQL IGQAESIKMD LATVQEKVGR STELLSSLRS
ERDRWSGGCD GFAQQMDTLV GDALLSGAFL AYAGYFDQQL RDVLFHRWVD HVHGAGVKFR
SDLARIEYLS TVDDRLQWQK NALPVDDLCS ENAIMLHRFN RYPLIIDPSG QAAEYIMKQF
AGRNIQKTSF LDDSFRKNLE SALRFGNSLL VQDVESYDPI LNPVLNREVK RTGGRVLITI
GDQDIDLSPA FQIFLITRDA SVEFTPDVCS RVTFVNFTVT SSSLASQCLN QVLRSERPDV
DKKRSDLLKL QGEFAVRLRQ LEKALLAALN ESKGKILDDN SVIGTLEKLK NEASEVAKKA
AETDKVMAEV EAVSAQYQRL AAACSQIFHT LQQLNEVHFL YHYSLDFLLD IFTFGGEPSY
DAQWDLLLGR SELFSSKTSH QSPPTALPYL TSQHMAALNK AQKLPGFENI MDIMCAQSAH
IKQWMAMDNP EAAVSSSDPI LLCSATGYDA SGKIEDLGIQ TGRQVTSIAI GSSEGFSQAD
AALTAASKSG RWVLLKNVHL APQWLGNMEK RLHTLKPHAN FRLFLTAEIH PKLPTSVLRA
SRLVVFEPAT GLKANLLRSL STLPATRLAK APAERSRLYL LICWLHALVQ ERLRYTPLGW
ANAYEFSDAD LRVACDTLDA AVDTVAQGRA NVAPEKLPWT TLRTLLSQCI YGGKIDNHFD
QILLDCILER LFTAKSFEPE HVLVRESMLK NLLKVSDDEL AFSGDGEKEA KPQWMAQLGE
LAQQWLKLLP KDMVRMKRTV ENIKDPLFRF FEREINLGSQ LLRDIRHDLM EILAVCRAER
KQSNETRALA SALQKGVVPT NWLRYTVPKD VTVMDWMVDF NERVKQLIRI GASDNLKREE
VWLGGTFSPE AYVTATRQQV AQANTWSLEQ LHLHVMIGRT DRLDVVRLTG SPQQFIFSHL
GMELRGAETT GGNALKLSDE ESPEGVRLPL YLYGDRRQLV TSLAFAVSPA TAFYERGVAL
VANSALS
//
