ID A0A0N4Y5Q9_NIPBR Unreviewed; 533 AA.
AC A0A0N4Y5Q9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=N-glycosylase/DNA lyase (inferred by orthology to a D. melanogaster protein) {ECO:0000313|WBParaSite:NBR_0001135801-mRNA-1};
GN ORFNames=NBR_LOCUS11359 {ECO:0000313|EMBL:VDL74948.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001135801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001135801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL74948.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; UYSL01020509; VDL74948.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4Y5Q9; -.
DR STRING; 27835.A0A0N4Y5Q9; -.
DR WBParaSite; NBR_0001135801-mRNA-1; NBR_0001135801-mRNA-1; NBR_0001135801.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR003265; HhH-GPD_domain.
DR InterPro; IPR023170; HhH_base_excis_C.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270:SF61; CD320 ANTIGEN; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00478; ENDO3c; 1.
DR SMART; SM00192; LDLa; 4.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 227..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..159
FT /note="HhH-GPD"
FT /evidence="ECO:0000259|SMART:SM00478"
FT DISULFID 349..364
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 462..477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 533 AA; 58926 MW; 620753E275A1BBF2 CRC64;
MVNKLAKLYG DPIIIDPTTN AKDVLDRFPE LGYAFPTLNQ LIAVQPELNA VLREQMFGYR
AASVAETVQQ LGELSPTCFD DVQQLSCDEI RKFLLSFTGV GPKVAECVAL MSLGQHQCVP
IDRHVFEVNL KFYEEKFGAY AGWAQAVLFN QQLEKFIHTT AISENNGVKK VNTPFGKMSN
PNNMYTPRST QQQAAQRVAD SPDLPKTRME RFRDYIGRTC CSCFLKLPIV VIVIAICILV
ALLLALIPAV VILTSAVDKE ALRSPAEEMQ ILRDTHVFPS PDMDDDEDLD SMRSFGASVI
HGIPSTALFP PNVSLCIGFG FACTNQPHLN FQRSLNFLQS TVISTTLRCD GKNDCPDGSD
ELNCKVCQSA FSCSISKKSK VKVCLRAEQL CDGITHCPDD YDEEEHCKKT CADDELRCPS
TSLCLPSTAV CDGVVDCETE DDEEDCKALC SDGTCLERSR ICDGIVDCSD GVDEEDCPEC
IGNHWNTYMC GATSHCFRRD EVCAPYTLCP NATKADKVFC AGRALRGMDW QDE
//
