ID   A0A0N4Y6F2_NIPBR        Unreviewed;       245 AA.
AC   A0A0N4Y6F2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Guanylate cyclase domain-containing protein {ECO:0000313|WBParaSite:NBR_0001165701-mRNA-1};
GN   ORFNames=NBR_LOCUS11658 {ECO:0000313|EMBL:VDL75247.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001165701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0001165701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL75247.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001436};
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DR   EMBL; UYSL01020572; VDL75247.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4Y6F2; -.
DR   STRING; 27835.A0A0N4Y6F2; -.
DR   WBParaSite; NBR_0001165701-mRNA-1; NBR_0001165701-mRNA-1; NBR_0001165701.
DR   OMA; CHESTAM; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   PANTHER; PTHR11920:SF498; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-8; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          58..188
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   245 AA;  27105 MW;  1DC4028DB36A4BE3 CRC64;
     MMEEYANNLE KLVSERTGML EQATVRADKL LSQLLPKFVA NELKNGRPVP PKMYAAASVL
     FTDVVGFTKL CGSSSPLEVV NLLNSVYSGF DEIINKNDGY KVETIGDAYM VVSGIPEENG
     RRHVSNVADI ALSIMEFLVT YRIPHRKSEQ LVIRLGFHSG PVAAAVVGLN APRYCLFGDT
     VNMASRMESS GEPGKIQLSQ ESMNLLQADY PEFITTKRGE MDVKGKGMCS TYWLLRKDRS
     CFTSS
//