ID A0A0N4YBC4_NIPBR Unreviewed; 1014 AA.
AC A0A0N4YBC4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Alpha-mannosidase {ECO:0000313|WBParaSite:NBR_0001375101-mRNA-1};
GN ORFNames=NBR_LOCUS13752 {ECO:0000313|EMBL:VDL77341.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Trichostrongyloidea; Heligmonellidae; Nippostrongylinae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001375101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001375101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL77341.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; UYSL01021134; VDL77341.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4YBC4; -.
DR STRING; 27835.A0A0N4YBC4; -.
DR WBParaSite; NBR_0001375101-mRNA-1; NBR_0001375101-mRNA-1; NBR_0001375101.
DR OMA; FIEYIAN; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF57; ALPHA-MANNOSIDASE 2X; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 405..484
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1014 AA; 115111 MW; 2DFBCD35AF47F7F9 CRC64;
MVRPIFRRKF RYIALITTAI FVLLYTRRDT IPHLKLSTLP KYDTSLHTTH LDTTEIAEWE
KSRKEGRAKP QENVPPVPHE ELEIIVVPFS HADPGWLKTF DSYSNDTNRI LSSAHEFLMA
NKDVTFLWAE TIFLERWWLK QNDSVKRDMR NLVKEKRLDL VTGSWVMSDE ATVYYPTSVD
NIVEGFHFIH NEFGMKPSLF ATLDPFGLSN SMAYLYTQAG VHREVINRVS AETKEVLRSN
RGFLFNWQQY FDDSKSSAML THLLYAHYDI WSSCGPDSKK CCQFDIWTNK VGRWCSLSKE
ITLEDAEQKA NTFVEQLKIM AGTYTSNVVM MLFGDDFRFS SLEEWEAQYS SLQRLFDEIN
KRDENIRIRF GTVSAYFDEL EASYKSSRTT PPSLTGDFFP YQTSHEWTGY YSTRPFFKAQ
ERRLLWMLHT ADLLFALRHQ QLPKTKEISE LLKKARRVLL LFQHHDAITG TSRKHVMQDY
SKQLHEAALS TESVIKKALA VTESTVNEFI EYIANNNATT ALKVLKITDK QIFVSILNTL
PYRLEDIVSV RVNSSQVGVV QEDGKPVESQ LDPYINRGEI DNATFLLSFR VRLLPLAKST
FILKSDTLAV VPEVRTAAEF VNKISNNISD VFKIAPFSTP TFSMKGGAIE STNDALTGGL
MGVTVSGSKT RIDLGHEFLV YSSSGGPYSM SVSEYVDYFS MRKLDSYLFV QGPVQDSVHI
FTKGLYYALT LKKVGGVQGE QLHYSIHLDV ASSKTSEVIK PAGLNHEVAF GLKMPFNESD
FYTDSIGLQL LRRRSETFFP MATSAVVEHN EYRITINTNV PHACRLTRGG TVETIIDRSI
HTDDGFGLAD GLADREDAIA NDNLPVDMKF TVLVENQGSS NSELFTTHTP AGHLSVQSTL
YPPVVLVGAE KPVVSTFIDT PPAPCHIQLV NVRLLPDGKH LLTIFVNGVT FDLYRQECGN
DIKPFLRSYL KQLDVKKLQT TDLSGIDRIG PEINVDQYSP EIVPFKFLSL LLTI
//