ID A0A0N4ZX98_PARTI Unreviewed; 1674 AA.
AC A0A0N4ZX98;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Parastrongyloides trichosuri (Possum-specific nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Parastrongyloides.
OX NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0001331200.1};
RN [1] {ECO:0000313|WBParaSite:PTRK_0001331200.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR STRING; 131310.A0A0N4ZX98; -.
DR WBParaSite; PTRK_0001331200.1; PTRK_0001331200.1; PTRK_0001331200.
DR Proteomes; UP000038045; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 3.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 29..167
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 1248..1427
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1446..1551
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1564..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1674 AA; 194321 MW; 6B955D1DED75263F CRC64;
MSPSAIGQGT STCMVRKATD ILHLLRDKIA LLPGSRDRHD HPIIIFPSRD SSYPLNVEDI
RNILFYLHSV TSSSSKGNGF IFIIDMRKGT KFDNIKPILK IIQDHFPGGI SNVLLIRPDS
FWEKQKASIS IGKYKFEVQI ISIESITKYI DASQLPNEFG GFMKYDHEDW IECRLEIENV
IWKICDILGA FDKFKNDMCK AEFPFDVPSA EQAIAQHTTV SKIIQDASME QMDNDIKKIS
HKITGGSINS PDDGYNSSLS ISSINPDLAS VIPHLGKLME TLRQSKDEIF KEWEHRRKSL
DHCYQLKLFE QDSEKLFEWI RSHYNLTVQR MTDLGDNEEI STIYLQDHVD FKKAAENTYV
SVTHILTVAK RLKEQGHVNK NKIENISKRL EEEWKIFEQR IEQRLTLLQL SVSFHQRARY
YLSNCNVWKN NIGIDPTNLV DAPSDKLEIA INEHEKFGDK INQAYAEAIA DGRSLSNQLK
TICNSSPELI QQISSFQLVS DMNQQITRAH KEIHSTWHKR KVKLHARLAR LAFKNDIQLV
ISWLEQHGEP YLSKNTAIGD NLQASKSLLK NHQHFKSVAS NTYSNAQKLF KASQTLMENG
ECDTKDMNNV VEDLRKRLDK FSERIEARTM LLNKAVLFYT HFMELMQWYD KQDTKASSYE
IVDIDVDICE KRRDEWIRET EATGQACATT ITEGQQLIKC LYIQSQTMNL DNKEVIKYID
MLIGQIEQRQ KLLSDRFGRQ RTCLQIGLRN ALLILDCEQI QVQLINWKKD MSNLISCEPD
KAENVLPFHN ENTYKVKKAV AEVKATGNEL LQAIDSNGIN LRNEFNEPIR DLIINSIKKV
KLLEDEVMQA SVNVCQRMEN AIQLNRIRMD ANRTIQIMQR EETQLLRMNR IPQNFEEAEA
FQEEHDNFQR IVEEKVRPST INFCQRAQGL RSNSISIEEN ETINEMIMNV TRKWSRLVCL
IEERSKLLKS ADACYKSLHQ NVLPILEQLE HDYKSDQKDF CSLKPYDKRT ELAKLIGEKL
EKHEQWKERF VKGSAYAQKT SENFLKYIRR CGAPEDHIKQ REEEIKNVKE NLRERQSRIL
KMWSNRKKAY EQCQQAVLIQ ATEQRISQWL QDEGETFMAQ LPTVVALKAS SHGKEQLESW
KNKLSEFKKI LKSEREQVKS FLSAAEGYLK NGINDIHSTT TERAMQKVKE NFNSFCQRMQ
EIELQILTSL GNQRNSGTKS EFSLDRVSDS SLDEKIQKRG SNGIVDAKLM EPMKELLKSE
RDYVSDLETC CNIYIKSYRS SISSLPGTLK GKEKEIFGNI EALTKFHSET FMKELEKYEE
NPEEVGNSFI TWMDKLNELY TNYCVNKEQN NHIISMQECI SFFNDVRQKN NLEHNKDLQS
MVIKPVQRIT RYRLMLEQLL KNAKSNIDEI KEAYDVVVDV PRRANDMIHL KRLEGYDEDD
VTMGEFVMQE NFVVSDNKHL FKKARERQVF LFELCIIFTK KIEVTPKIHK YVIKDKLMLS
DVSIREHVEG DICKFSLRMG NLPNSDMSID LKSKTEKSKM IWIKKIRDLM QGLLQYNIAI
QPLTNGPDSK RSSRNSGMSK DSNELISINE PINENSHKPV SERLQVKQIT NYEVYKQNAE
NETTPDLKNS TETQNNHILS PAKKVQEKIL TNGDVNEVVP KLYDILSTVS FNDE
//