ID A0A0N5A0I5_PARTI Unreviewed; 657 AA.
AC A0A0N5A0I5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Carn_acyltransf domain-containing protein {ECO:0000313|WBParaSite:PTRK_0001493200.1};
OS Parastrongyloides trichosuri (Possum-specific nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Parastrongyloides.
OX NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0001493200.1};
RN [1] {ECO:0000313|WBParaSite:PTRK_0001493200.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR AlphaFoldDB; A0A0N5A0I5; -.
DR STRING; 131310.A0A0N5A0I5; -.
DR WBParaSite; PTRK_0001493200.1; PTRK_0001493200.1; PTRK_0001493200.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000038045; Unplaced.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.1280.180; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF16; CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 54..643
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 377
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 657 AA; 74114 MW; 1D1CE3C803E63F24 CRC64;
MFNNMKRIPI LKGSVCSTKN VMIRSVTTLH GDEYNFIHKS KLPTFKYQKS LPRLPIPKLE
KTIERYLNAA EAVLPESKFS KIKSLTKEFE ASEGKELHEL LVNHDKANKH TSYISEPWFD
MYLSSRDPCP VNFNPFMMYA PDKDPKQNDQ LTRATNFVIS YGRIKKALDK GCLDPEVFFM
KPEVKDSFLY NLLVKSSPDV ISWYVGYLFK AFALDMSQYG NLFGGSRIPE IGKDRLHLNR
SSNYFVVAKG GNFYKVQLFD NSENILRPEV IQSSLAKILS STSIVDDNCA VGSLTCANRD
TWAKARKNLE KSHISSDSLA AIDSSLFLLC LDDLNSTDPQ ELVQSLLIGF NGANRWFDKC
FQCIVDKNGQ ASINFEHSWG DGVAVLRLMN ESKKDTENNR FVTSEDKVDT SINVDKYVKR
LEFELTSEDK ANITEIQKEH LTRNSNLEFS TVEYSGLNKN LIKKCKVSPD SIMQLGIQLA
YYKTYKEFVP TYESASTAAF LRGRTECVRS ATIDTKNVVL AITEGKSNVN DLIRKASSTH
YKLCKEAAMG EGIDRHLLGL KIMAQKYNKP TPEFYNNDIV QYMNHFIIST STLSSDTIVF
GGFGPVVSDG FGIGYNVSAD KMGAVISAYK NQKSAHEFAD SLHSGLDEIK FNLTKEV
//
