ID   A0A0N5A7P7_9BILA        Unreviewed;       329 AA.
AC   A0A0N5A7P7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=phosphoethanolamine N-methyltransferase {ECO:0000256|ARBA:ARBA00035674};
DE            EC=2.1.1.103 {ECO:0000256|ARBA:ARBA00035674};
OS   Syphacia muris.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX   NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000005401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMUV_0000005401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine =
CC         H(+) + phosphocholine + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:25325, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:58641, ChEBI:CHEBI:59789, ChEBI:CHEBI:295975;
CC         EC=2.1.1.103; Evidence={ECO:0000256|ARBA:ARBA00035588};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25326;
CC         Evidence={ECO:0000256|ARBA:ARBA00035588};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-methylethanolamine phosphate + S-adenosyl-L-methionine =
CC         H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:25321, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57781, ChEBI:CHEBI:57856, ChEBI:CHEBI:58641,
CC         ChEBI:CHEBI:59789; EC=2.1.1.103;
CC         Evidence={ECO:0000256|ARBA:ARBA00035580};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25322;
CC         Evidence={ECO:0000256|ARBA:ARBA00035580};
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004969}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A0N5A7P7; -.
DR   STRING; 451379.A0A0N5A7P7; -.
DR   WBParaSite; SMUV_0000005401-mRNA-1; SMUV_0000005401-mRNA-1; SMUV_0000005401.
DR   Proteomes; UP000046393; Unplaced.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR040516; PMT2_N.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR44307; PHOSPHOETHANOLAMINE METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR44307:SF2; PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1; 1.
DR   Pfam; PF13489; Methyltransf_23; 1.
DR   Pfam; PF17987; PMT2_N; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          12..65
FT                   /note="Phosphoethanolamine N-methyltransferase 2 N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17987"
SQ   SEQUENCE   329 AA;  37286 MW;  44BFACF3533804E4 CRC64;
     MFGFTDGYLA TEKVNGLTAA LDVYRTVEGN KTVGFDFKSL KEVDASIHTS QNFLDLYWVL
     KKSEFLPEDG SESKTFRDFL DKTQYTDTGI FAYEWIFGDN FISPGGAAEN LKILKQLGDL
     KSGQTMLDIG VGIGGGARQA AAEFGLHVLG IDLSSNMLSI ALDRLQRDKD TRVRYSITDA
     MKCEYPPESF DYIFSRDGLH HNDNLGLLIK RLHKCLKPNG RILITVYGKG HGKFSKKFSE
     YVANRQYHLL NLEELIHIFE EAGFKNVKGV DLTQRFKDIL MDELTKAKTH KSDFLKVSKY
     EGIVNGWMDK LGYIEDDNHC WLQVSADRD
//