ID   A0A0N5AEH5_9BILA        Unreviewed;       951 AA.
AC   A0A0N5AEH5;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Alpha-actinin, sarcomeric {ECO:0000313|WBParaSite:SMUV_0000263301-mRNA-1};
OS   Syphacia muris.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX   NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000263301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMUV_0000263301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the alpha-actinin family.
CC       {ECO:0000256|ARBA:ARBA00010255}.
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DR   AlphaFoldDB; A0A0N5AEH5; -.
DR   STRING; 451379.A0A0N5AEH5; -.
DR   WBParaSite; SMUV_0000263301-mRNA-1; SMUV_0000263301-mRNA-1; SMUV_0000263301.
DR   Proteomes; UP000046393; Unplaced.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd21214; CH_ACTN_rpt1; 1.
DR   CDD; cd21216; CH_ACTN_rpt2; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 4.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF422; PH_9 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00435; Spectrin; 3.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00150; SPEC; 2.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   SUPFAM; SSF46966; Spectrin repeat; 4.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          54..158
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          167..273
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          809..843
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          552..579
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   951 AA;  111001 MW;  00A20D8701DAD2AE CRC64;
     MMSLLLRPYE KQIMVDYYQQ LPATNNNQYP PGYDPTQQEE EWDREGLLDP AWEKQQKKTF
     TAWCNSHLRK AGTSIEVIEE DFRNGLKLML LLEVISGEPL PRPDRGKMRF HKIANVNKAL
     EYIESKGVKL VSIGAEEIVD GNVKMTLGLI WTIILRFAIQ DINVEEFSAR DGLLLWCQRK
     TAPYDNVNVQ NFHTSWKDGL AFCALIHRHR PELIDYSKLS KADPIHNLNL AFEIAEKHLD
     IPRMLDAEDL VYSQKPDEKS VMTYVSCFYH AFRGDMVNNV PDEKAVMTYV SSYYHCFLGM
     RKAETAAHRI CRVLKVNQDN ERMMEDYESL ASDLLAWIRH WMPWLSSRST DDNLDLVRRK
     LEDFRNYRRH EKPPRIEEKG KLETLFNTLQ TKLRLSNRPA FMPTEGHLIK DINAAWRGLE
     DSEKGFEEWL LCEMMRLERL EHLAEKFRRK CAMHEEWAHG KEAILQSNDW RSCGLYMIKA
     LRKRHEAFES DLGAHQDRVE QIAAIARELN NLKYPKIAAV NSRCQPMIMI ISSKWAFFQS
     ICDHWDLLGS LSQQRRRQLE EAERVAENLD RLYLDFAKRA APFNNWLDST REDLADLVVV
     HEMKEIQDLV QSHNTFKTTI PDADAEFKSI ASIEQEIIRL IEQHGFDREL IKNPYTDLTG
     AELHRKWIEV QQAIPKRDNQ LQQELHRQQN NERLRQLFAE KANKVGPYLE RQLEQVLAIG
     LGGRGSLEGA ISQLKNIHQQ AMAYKPNLDE LEKINQEMQE NFVFENRIAR YSMESLRVGW
     ESLMTSINRT INECENQILM RDSKGITEEQ LNEYRASYNH FDKDRQGLDQ EQLKSCLISI
     GYNIRPGKEG DQDMARILAV LDPNRIGRIP FDAFLDFMTR ETGDADTAEQ MVDSFRILAS
     GKPYITVEEI RRELPADQAE YCIERMSSYK SINGPPGCYD YVAFSHSLYS H
//