ID A0A0N5ALN6_9BILA Unreviewed; 2771 AA.
AC A0A0N5ALN6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Myosin light chain kinase, smooth muscle {ECO:0000313|WBParaSite:SMUV_0000546101-mRNA-1};
OS Syphacia muris.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000546101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMUV_0000546101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR STRING; 451379.A0A0N5ALN6; -.
DR WBParaSite; SMUV_0000546101-mRNA-1; SMUV_0000546101-mRNA-1; SMUV_0000546101.
DR Proteomes; UP000046393; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 22.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47633:SF7; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47633; IMMUNOGLOBULIN; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 20.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 20.
DR SMART; SM00408; IGc2; 20.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 20.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 19.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..83
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 88..181
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 233..488
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 567..658
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 780..870
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 888..975
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 986..1070
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1072..1154
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1167..1257
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1271..1357
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1383..1476
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1480..1571
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1592..1683
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1691..1780
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1804..1895
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1909..1999
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2016..2105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2253..2342
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2361..2453
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2465..2558
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2570..2658
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2670..2759
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 2211..2235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2211..2225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 262
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2771 AA; 309647 MW; A1DB6567A196208E CRC64;
MKYSACPLLY SNLTVWKPEP KVQWYDVSGN EITKSTEHYK ISTTGKQTTL EICNIQVDDK
GTYTLKVSNE IGEDKCEIPI QVADRPVPPG RPIVQDQNAD SVKLLWATSM QDGGSPIRHY
TVEMKKESDE KWSRAEIIKQ PFTTLFNLVS GESYRFRVCA DNIFGSSDPS EESESVYICD
MTRAVVEPAE DETVEDNLGS TAIDYDSLTN NSEPVVYRTI NVNRLRNDFK SKYIVKEELG
RGAYGTVYRV IERATGKSWA AKVVQVRPGV KKEAVFHEIH MMNQLHHPKL LNLHEAFDLD
TEMVLIEELV SGGELYEKII EDDTLMAEEE VRDYVHQILL GVQYMHENNI VHLDLKPENI
LLKSNNSTDI KIIDFGLARK LDPNKNVKLL FGTPEFCAPE VVNFQPVGLS TDMWTVGVIT
YVLLSGLSPF LGENDEETLA NVSAGDWDFD DPSWDDVSPL AKDFICRLMI KDKRRRMTVA
EALQHPWIKG PLLSAFNDLS EYVKQTQTPT ERDQIPLRQK RNFLARKRWS DDILPMGRLV
KRGAIFRRLS MDGVFEREIT FETEYAPKVC KQLEDIIAKV GDLIATLSCD VDGIPAPRIT
WFKDGKEILI NNTTKYASQY SNGVAELHIK SINKDDSGVY KMEATNEIGS INSVATLSVE
KTSKKKSVRE SESRKLEGNR PAFLHNLSDK SVKLNEPLIL TVTCSTLPEP DVQWFRNGEP
IDLNSRKYIL KHDKGRYELE ILSCGAEDDA EWKVHGNNGF GECESSCKLT VEIPNDLKAP
EFVTPLKDII CNEMEMLRLE TCVLANPLPE ITWYRNNDEL YHGNHHSLIF DDQKKNYSLI
VSDAYAEDSG NYRCVAKNSV GVAECSCFVT IKEAEIQPVK LIDDGKSPKF KMHLPNRAVP
EGFELTLVCA VTGSPNPEIK WLKDDKEIDS TSNDMKYENG VCTFTIFSTT LKDAGVYSCV
ATNSYGTASS SCTVEIQAYD SMDLKPKFKQ QLMDVSAIEG SEIVLECVVV GKPTPTVTWY
KDGLKLFLEN RMLQYTDRKG VSRLNIMNVL KDDSGEYSCE AVNKLGKDFT HCVVKIVGNR
ELLEVEVTAN PKPYIEWYHN GKLIAESRTL RTYFDGRIAF LKVYEADEKH QGQYLCRATN
KLGSAETRCT VVVSPRPGLD DQIPNMPKFL QKLQDISVKK EDDTVTLTCQ VHGTPRPEVQ
WLFNGRAIHN NSNIRIRAFD DNVCTLQIAR TSRDSCGTYT AVAHNIYGDA HSSANVVFLE
QSTTVIENTV PKFIVEPPSK IVVEAGNILC ITCDIDGIPE PEVTWFKDGH PIKNGHATIK
KDSLTHQLLI GGVDNTDEGE YVVKAENVLG SEQRRITVEI INSSVHGEKA EISTGQNQMP
EAPTGPLVAE EIETNNLVLH WGAPLENNIE KVNEYVVERR SPDEQHWIKI GTTAQATFRA
DKLASDAEYF FRVSAHSKIG WSKYLTTSSA IKTLPSGMKP VLSNIFPETL SINEMENFTI
EASYSGKPQP VIKWYRNGME IKANKSNVTI KTGENKSVLT VKKPKLGIDD GVYSCHAEND
AGHAFKETTV IINSNEVLVD RGKNRQVPNE APTIVKQLAN VTVAGEQQFV LLCKVSGSIP
YQVSWYKNDS TVSSCGRFQL DSSESGTYKL ICHSAQVDDM GIYRCVLNNA VGIAQSSCKV
NVTDKQGQKP PTFEKTLSDC TVIAGSEIKL KCRVIGNPDP QVVWMKDGEQ LSTSRRITLR
FIEDGYCLLL ISNVNSSDTG IYLCSAKNVV GVDSTQAMLT VADETGPDRH LVTADSKEKR
YLKPEFVRVP SSIIESSEGS TVKLIARAVG QPMPLITWKK DGKEITRGNP LYETRVTPIG
ESVLIISCVT VKTAGIFACC ASNSEGTVES ESNFIVHSRT HKRPHEEPPR FSIELVDTGV
AIGHSAKLKC AVQGIPEPQV QWYFVDDSRK STLIRSTLNS LWTEYRKGEI CELRADAVVS
IQQGTYQCVA VNEYGKALSQ CYVLVGNPSD EPAGPPRFLR CLRDIWSPVG SEVVFEVEVE
GHPLPELSWY HNDKKVVEDR TMKISYTSRS RCELRISPLS LKHLGSYSVV ASNVHGVLVT
SAALNASPDN KIAEPPKFLQ SLQQQGIRIS KSEEYRKFSE VTEAVVPDIV KLEKEKRLLK
KEMKKGDAPR FIRGLEDQEF REGDVAALAG KLSRKHRSRV MYGQAILKDK NNKNLREKEG
ATHDSDATST SESSTIEDVR MAIAERNKKI CRPKFMVKPK QNKTIEENKS LRLKAAISGN
PAAKVRWDKS GIVLETGNKY SIYHDGDFYY LEVHHMSKFD EGFYNCTASN SEGIATSTSE
IIVVAPKDPL QRRSRKEPKA PSFLEVLPGK VKLTSNELFS VECSISAYPA PSISWCRNGN
SFIPKGDRCM MLYDGETATL KIAGVTSADV GTYTCVAENH LGQAKTSMQL DVEQSTSESE
HGIVPMFSTE RFSEPIIACD GEKVVLSAEL VEGSEPLSVI WMHDKVEISD SSGFTYSKKK
NYYCMTIADA FPEDSGEYIC EARNKFGAAQ CFMNLHVSER SNKHEYEEPP EVIGAEKIVK
VDPGNTICLN ALVRGHPEPV IVWQRRGKML IAGDRYEMKH QGEKFTLLIN DATREDTGPY
CLEAMNSAGT ATVEIVVEVN EITETNAVVP KFVCVPISIQ CAYGQKAELK CEFKGKPQPV
VSWFLNDNKI VSGRQGYRIK TSTSASQLTV LRLKESHLGE YLCVIRNSYG EDLAKARIML
EGTSAALPPR R
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