ID   A0A0N5ATK6_9BILA        Unreviewed;       966 AA.
AC   A0A0N5ATK6;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=COP9 signalosome complex subunit 6 {ECO:0000313|WBParaSite:SMUV_0000816601-mRNA-1};
OS   Syphacia muris.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX   NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000816601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMUV_0000816601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU003435};
CC       Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC   -!- SIMILARITY: Belongs to the peptidase M3 family.
CC       {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC   -!- SIMILARITY: Belongs to the peptidase M67A family. CSN6 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010893}.
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DR   AlphaFoldDB; A0A0N5ATK6; -.
DR   STRING; 451379.A0A0N5ATK6; -.
DR   WBParaSite; SMUV_0000816601-mRNA-1; SMUV_0000816601-mRNA-1; SMUV_0000816601.
DR   Proteomes; UP000046393; Unplaced.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06457; M3A_MIP; 1.
DR   CDD; cd08063; MPN_CSN6; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR   InterPro; IPR024969; EIF3F/CSN6-like_C.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR033851; M3A_MIP.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR033859; MPN_CSN6.
DR   InterPro; IPR024077; Neurolysin/TOP_dom2.
DR   InterPro; IPR045090; Pept_M3A_M3B.
DR   InterPro; IPR001567; Pept_M3A_M3B_dom.
DR   PANTHER; PTHR11804:SF79; MITOCHONDRIAL INTERMEDIATE PEPTIDASE; 1.
DR   PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF13012; MitMem_reg; 1.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU003435};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU003435};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT   DOMAIN          36..173
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
FT   COILED          409..439
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   966 AA;  108979 MW;  9034CE2C18DA97CF CRC64;
     MEVTTENNSN ATAVKSSLEM ANGKERNALQ KAEAEISLHP LVIMNISEHW TRLRSQNVER
     KPVQVYGAVL GKQIGRHIEL INSFEIKLNE AEGGLSLDEE FFVTREGQYK EVFPDLDLMG
     WYTTGVDAPT DSDLYIHKQI IKIRETPVMV KLDPQSSNSD KVLFTLFHSA YILFFKLPIA
     VFESLVNPSD ETSMQWQRIP WALASEQAER IGIDHIAKIS TTTKNSKSQT SSQVAGQYSA
     VNMLQTRLQL ILDYVVAIQK GELPRNEAII REIALLVRRL PVLDFNRFDE DFKNQCIEAK
     LTLHVLSMAK ICGILNSGLF GVQLLTDQFG FSALNKVVAE RCNKIVDSVS LYPLILNPTG
     TSKTVKLFDD LSNEICCAAD LTECVRCLHP GTEYTSAAEK SMHEYTLLVE SYNTNAKLYE
     ALKNSLETQR EQLNEVDIRT IQLFLKDFEQ SGIHLPYDKK SQFVKISGSI FDTGSKFIAE
     AEKPVCVNLL ERRKYGSGSY LTGPTTSTLS TASRKWSYAT YYRHSALQES LLRQLISCRH
     RLAELTGFKT YAHRAQMFSI LGSYDRAHEF ITSIIKACRP SAERELTVLM DVLTQCDPDA
     TKIGEWDLQF LCSVYRRKVF GSLYNLREFF TLRNLMKGLE SVTDKWYGLK FVLSRPEEGE
     IWPGNVFKLD VQSSDSKSMG TIYLDVQDRS NKSMGPCHFT VRCSKLLDDK TYQLPIVVVS
     VPFASEFQEL DQIQLNPHQA ENFFHEMGHA FHSILGKTEY QHVAGTRCPT DMAEIPSNLM
     EYFFNDINVL QKMAFDGNGN AISVEDAASM IASRFAFTSI DLLQQAVYSL FDLEIHGENA
     EGIISGKFTT TDLFTSIWKN VFPEVELAPN SAYHHRFTHL VPYGAKYYSY LVARAAASLI
     WNLRFRDDPF SSESGQNWAK VQSFGGSLPS MNLLQMSLGY IPTNHTLADA VCDEAKCSCQ
     GTGVSL
//