ID   A0A0N5BNA9_STREA        Unreviewed;       847 AA.
AC   A0A0N5BNA9;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Discoidin domain-containing receptor 2 {ECO:0000313|WBParaSite:SPAL_0000738800.1};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000738800.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0000738800.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   AlphaFoldDB; A0A0N5BNA9; -.
DR   WBParaSite; SPAL_0000738800.1; SPAL_0000738800.1; SPAL_0000738800.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   CDD; cd00057; FA58C; 1.
DR   Gene3D; 2.60.120.1190; -; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR048525; DDR1-2_DS-like.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   PANTHER; PTHR24416:SF600; PDGF-AND VEGF-RECEPTOR RELATED, ISOFORM J; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF21114; DDR1-2_DS-like; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00023137}; Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transferase {ECO:0000256|ARBA:ARBA00023137};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT   TRANSMEM        414..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          39..195
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
FT   DOMAIN          570..833
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          54..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   847 AA;  96973 MW;  0B370B72EC110A3D CRC64;
     MLILNFSSTY SHQYNSQSMI FLLMSLLISI INGLELRECN KALGMENGRI KDSQITSSSS
     YDEQSTGPQH SRIRTETGAG AWCPMSQINM SSNEWIEIDF PTNMVITAIE TQGRFGGGEG
     QEYTPMFKIR YKREGMGPWA RYKDSSNNEF IKANSDTRTS VLIPLDGSII ASRIRLYPLS
     YKTRTVCLRL ELHGCRYNGV LDGYTITNGG IIDGLEMRDF KFDGNTNDTI KTKGYGKLYD
     GKIGEDNFDD KPNHWIGWKN EDVKGKVTMK FYFKDKQNLT GVNFYTNNFF KLKSMIFKKA
     IIKISPTGDE KTFSKRSIEF SYEPDLIYPS SRWVRIPISS RIAKLIKVDL YLQSAADFLL
     ISEVKFETNR ILFDTDIDDP LLSSENDDII SLDETKNSLT FFAINEVPDN LTNYVLIVVI
     IFISLSLLIC STLIYVMFFC RKEAQQKNTL LPIFKKQNVQ MIIKDDSDTI KRSFKSGTLM
     ESKNIPSDSS SDYADPDYSV CVEQPLLNRM YYSTECGTYN IFSQGTLTSN LSNTSSTISS
     PNTCYRNCNK EIEEFLFNMD HIVKINPSVL IHVEKLGDGE FGPIDLCRLE HRLVASKKLK
     QTATKDEFIN FKKEIIVMSS LKHQNILEVI GISIEQPNNT ICCIMEYMKN GDLCQYLQSQ
     NFNTLTTEFL LSIATQIAAG MSYLESQNFV HRDLAARNCF VDEDDIVKIG NFGMARSLYS
     SDYYVVEGKV NAPIRWMAWE SLLLGRFTTK SDVWHFGVTL WEILMGGYDK PYSKLTDNEV
     IENLECIYNS GRLRTYLPRP RHGNSILYDE LMLKCWQREE HNRPTFSSIH CFLQKMTCNH
     ARGSPKS
//