ID A0A0N5BQ63_STREA Unreviewed; 1951 AA.
AC A0A0N5BQ63;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Sema domain-containing protein {ECO:0000313|WBParaSite:SPAL_0000803300.1};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000803300.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0000803300.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 174720.A0A0N5BQ63; -.
DR WBParaSite; SPAL_0000803300.1; SPAL_0000803300.1; SPAL_0000803300.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR CDD; cd11236; Sema_plexin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1275..1297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1931..1949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..498
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1951 AA; 220574 MW; 8E220BDB65A289C7 CRC64;
MLICLFPSII FSTSKTIVNI FENPNNDMPL QKLVVDKTTE RIYVGGVNYI YDLKPSLEKR
ATAITGHDNE FKPCSDIKLC SHDRVHLKAM AVYAEGSKLI ECPSTYPQCR LRNLYDITTP
DEIKGISHSM IYPDETASTV ILVGMGPPNP SYTYCQPPEN YDIWKNDLSQ VLYIGSTILN
NNALQLTIPS TSLEAPPSIA SYKLNGSDSE LFNLAIKSVG DGTELKLLDK NYKIDYISAF
QSGAFIYFST QQLESFHNEF NGGLFSPETV SKLVRIYVND HHFHSYTEVP LICKGRDGYN
YKYIKDTYLA KPEYTLAKRL GVRVEEDVLF AIFSDQPSNT SPQQVVNSAL CVYSMDTVER
IFKDNIRNCF RGKTSRNLKW FVKNDKCSNT TISESQMICG SDAIRFIGGE KRIDGEVLMN
KENTEFTSIV VHSVKGFTVA FIGTVNGKLL KVAIQKDDFY IYNTIDISNN PILPDMELDG
NNEYLYVLTS DRLTKLAIKQ CGDATDCKSC LEMRDPYCGW CGISGMCVSE DQCISLDIPP
SPTEFFSQNG KCPIILSIFP NSTQISTTQN ISIVMQNIPQ RNYKFIGCRF EFPYLNINVT
QPAVVIDGFN QKIYCQTPDV LLIPTIPIDE MALNSKLNII RTNTNTSAIS LASTNFTFYD
CRKLYSCKSC VESSYPCSWC IQSSQCVEVT SSDATCKNQN FVHGIGTSKL SNKGSLHCPQ
IVEMESTYIR AGEAKQFTVA TRNTHSFMKD WVCIIKNVHE IIEVSGNKVG DQIICDSVKM
DYTNSKFNNG TLNIEIVLAW ASKNQRQPLD NIFKVNLYKC NFMADNCGSC LLLDNTKFNC
GWCESTGKCS PQSACLRRTD FLKTGDICAN PKIINFYPKK GPLNGGTELT IIGNNLGRQV
SDVDNNVFIG NVRCSVITSK YVPFSKIVCK TGDKLKIEQN ANLPRNRARS HPIIVQMETK
KGNLSYTATS NEPFVYVDPL ITTFSPRQGP LSGGTMVTIK GENLDAGSHV RTFIGGSLCK
IVSRNSTSLI CQSGSNDSPN NGSVHVVFDD TPIEFKNLQF EYKPNPKFLS IDKDMSIVSG
GISITVKGVG FNLIQSARMV FGVDDQIVKG YFCNIEHDTS MNCTTPNIQN VGKIRPTNNN
PLSVNYGYFI NEYFYVNDSR SLQNYKQISV YPDPTLESIK DIRYFLPGGF LTINGESLNK
VASEDDIKVD VSGNECKITA LADKALTCQL PNKDEIDETK FDSLGPEVLV KIGSNVAEVG
RLSFDPKATK LTTQFLFIII LAVVLFFIAF LILLILFKRK STSHNRQLKY LRSQMDTIEM
RVATECKEAF AELQTSMSAW QENYPQGQIY TPFLSYKDYA SRILFPHNYP NNPIFAHLEV
DSEHASAIEA GLQQFNKLLC NKTFLLTFVQ TMEKNKYFVG KDRVNVGSLL MVVLQDKMEY
CTDILKQLLK ELILKNVEGK YQPKVLFRRS ESVAERMLSA WFAFFMYKFL RDCGGQQLFQ
LYWSLKQTTE KGPQDAITMD ARYSLSEEKL LRSTIDYQEL IIHIISDEID SPQSQKILPQ
EFTIRAISCD TISQVKEKCL DAKYRTLPFS ERPSIDDIDL EWVTPSQSII LRDIDNSNKI
ESGGWKKINT LSHYKIPTNA RLLLIPRQIA SSYNLSLMSD RSEKSSLTMI NNSPTLGRGF
GTNSSNNSKE CSNHFHLIKP QENGPSDHQE KLVSEVYLTR LLTMKGTVQK FIEDFFNVIF
SSSGNSRQFF FPICIKYMFD FMDEQALEHG ITDEEVVHAW KSNALPLRFW VNLIKNPHFL
FDIPKPTKIE GSLNVIAQTL MDACSTQEQN LTKDSPSSKL LFAKDIPSHR MKVNRYYSEI
RRMPPISEHE MSSYFADESK LHQNQFYIYT ALNELYSYVE QYKESIYDEL STNEYANSQG
ITAKFQQMID IMSILIITLT VLLMDIIVLQ D
//
