ID   A0A0N5BTH3_STREA        Unreviewed;       438 AA.
AC   A0A0N5BTH3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=PUA domain-containing protein {ECO:0000313|WBParaSite:SPAL_0000915600.2};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000915600.2};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0000915600.2}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC       {ECO:0000256|ARBA:ARBA00008999}.
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DR   AlphaFoldDB; A0A0N5BTH3; -.
DR   STRING; 174720.A0A0N5BTH3; -.
DR   WBParaSite; SPAL_0000915600.2; SPAL_0000915600.2; SPAL_0000915600.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd02572; PseudoU_synth_hDyskerin; 1.
DR   CDD; cd21148; PUA_Cbf5; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   Gene3D; 2.30.130.10; PUA domain; 1.
DR   InterPro; IPR012960; Dyskerin-like.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR002501; PsdUridine_synth_N.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR004802; tRNA_PsdUridine_synth_B_fam.
DR   InterPro; IPR032819; TruB_C.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   NCBIfam; TIGR00425; CBF5; 1.
DR   NCBIfam; TIGR00451; unchar_dom_2; 1.
DR   PANTHER; PTHR23127; CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5; 1.
DR   PANTHER; PTHR23127:SF0; H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1; 1.
DR   Pfam; PF08068; DKCLD; 1.
DR   Pfam; PF01472; PUA; 1.
DR   Pfam; PF16198; TruB_C_2; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   SMART; SM01136; DKCLD; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   3: Inferred from homology;
FT   DOMAIN          31..89
FT                   /note="Dyskerin-like"
FT                   /evidence="ECO:0000259|SMART:SM01136"
FT   DOMAIN          280..354
FT                   /note="PUA"
FT                   /evidence="ECO:0000259|SMART:SM00359"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   438 AA;  48724 MW;  51902CCB95A83382 CRC64;
     MGKKSKEGKK SKEEVKDEYI LPSSTEPGKM NSEEWPLLLK NFDKMNVRTN HYTPLPDGCS
     PLQRDLKNYV SSGYFNLDKP ANPSSHEVVS WIKRILRCEK TGHSGTLDPK VSGCLIVCID
     RTTRLAKSQQ GAGKEYVAIF KLHNSVDGEK PIRNALEKLT GALFQRPPLI SAVKRQLRVR
     TIYKNTLIEY DNEQNMGIFR VSCEAGTYVR TLCVHLGLLL GTGGNMLELR RSRSGVTSEH
     DGLVTMHDIL DAQYLYDHQK DDTYLRTIIR PLEALLIGHK RIVVKDSAVN AICYGAKILL
     TGVLRYDDGI EIGKEIVIVT TKGEAVCIAI AMMTTATMCT VDHGIVAKTK RVIMERDTYG
     RKWGLGPVAS RKAQLIKEGK LDKYGKPNAS TPAGYISAFV DYSATTNSDN RKREATDDND
     TVPEKTSKKS ESSSDDSD
//